Yung feng Liao
Research Fellow, Academia Sinica
Location: Taiwan
Consulting Services
Areas Of Interest
Professional Narrative
I obtained my Bachelor degree in Zoology from National Taiwan University in 1987, and a MS degree in Biochemistry from National Yang-Ming Medical College, Taipei, Taiwan, in 1989. After working as a research assistant at the Graduate Institute of Biological Chemistry, National Taiwan University, Taipei, Taiwan, I joined the research group of Prof. Kelley Moremen at the Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA, for my PhD research, and obtained my PhD degree in 1998. After completing postdoctoral fellowship supervised by Dr. Livingston Van De Water at the Massachusetts General Hospital and Dr. Michael Wolfe at the Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, I successful secured a faculty position at the Institute of Cellular and Organismic Biology (ICOB, previously known as Institute of Zoology), Academia Sinica, Taipei, Taiwan in 2002. Since then, I have been the principal investigator of the Laboratory of Molecular Neurobiology at ICOB, Academia Sinica, Taiwan, and have directed an independent research program that aims to solve the pathogenesis of Alzheimer’s disease, and neuroblastoma, and related neurological disorders. Currently, I hold the rank of Research Fellow at the ICOB. I have published more than 60 papers in reputed journals and have been serving either as an editorial board member or as a peer reviewer of prestigious journals.
Employment
Education
Referees
Publications
Publons (https://publons.com/wos-op/researcher/1537485/yung-feng-liao/)
1. B.-J. Wang, G. M. Her, M.-K. Hu, Y.-W. Chen, Y.-T. Tung, P.-Y. Wu, W.-M. Hsu, H. Lee, L.-W. Jin, S.-P. L. Hwang, R. P.-Y. Chen, C.-J. Huang, and Y.-F. Liao*. (2017) ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A., 114: E3129-E3138. (https://www.ncbi.nlm.nih.gov/pubmed/?term=28351972)
2. N. Bhore, B.-J. Wang, Y.-W. Chen, and Y.-F. Liao*. (2017) Critical roles of dual-specificity phosphatases in neuronal proteostasis and neurological diseases. Int. J. Mol. Sci., 18: E1963. (https://www.ncbi.nlm.nih.gov/pubmed/?term=28902166)
3. A. C.-L. Lee, Y.-Y. Shih, F. Zhou, T.-C. Chao, H. Lee, Y.-F. Liao*, W.-M. Hsu*, J.-H. Hong*. (2019) Calreticulin regulates MYCN expression to control neuronal differentiation and stemness of neuroblastoma. J. Mol. Med., 97: 325-339.(https://www.ncbi.nlm.nih.gov/pubmed/30612140)
4. P.-Y. Wu, P.-Y. Chuang, G.-D. Chang, Y.-Y. Chan, T.-C. Tsai, B.-J. Wang, K.-H. Lin, W.-M. Hsu*, Y.-F. Liao*, and H. Lee*.(2019) Novel Endogenous Ligands of Aryl Hydrocarbon Receptor Mediate Neural Development and Differentiation of Neuroblastoma. ACS Chem. Neurosci., 10: 4031-4042. (https://pubs.acs.org/doi/abs/10.1021/acschemneuro.9b00273)
5. P.-Y. Wu, I-S. Yu, Y.-C. Lin, Y.-T. Chang, C.-C. Chen, K.-H. Lin, T.-H. Tseng, M. Kargren, Y.-L. Tai, T.-L. Shen, Y.-L. Liu, B.-J. Wang, C.-H. Chang, W.-M. Chen, H.-F. Juan, S.-F. Huang, Y.-Y. Chan, Y.-F. Liao*, W.-M. Hsu*, and H. Lee*. (2019) Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma. Cancer Res., 79: 5550-5562. (https://cancerres.aacrjournals.org/content/79/21/5550.short)
6. P.-F. Wu, N. Bhore, Y.-L. Lee, J.-Y. Chou, Y.-W. Chen, P.-Y. Wu, W.-M. Hsu, H. Lee, Y.-S. Huang, P.-J. Lu, Y.-F. Liao*. (2020) Phosphatidylinositol-4-Phosphate 5-Kinase Type 1α Attenuates Aβ Production by Promoting Non-amyloidogenic Processing of Amyloid Precursor Protein. FASEB J., 34: 12127-12146.(https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202000113R)
7. N. Bhore, B.-J. Wang, P.-F. Wu, Y.-L. Lee, Y.-W. Chen, W.- M. Hsu, H. Lee, Y.-S. Huang, D.-I Yang, and Y.-F. Liao*. (2021) Dual-specificity phosphatase 15 (DUSP15) modulates Notch signaling by enhancing the stability of Notch protein. Mol. Neurobiol., 58: 2204-2214. (https://doi.org/10.1007/s12035-020-02254-0)
Grants,Awards and Certifications
Grants :
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To promote the autophagic clearance of tau as a novel tau-targeted therapeutic approach for Alzheimer’s disease |
2020/01–2021/12 |
Academia Sinica |
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Cell-based Assays for g-Secretase Substrate Selectivity |
2017/01–2019/12 |
Academia Sinica |
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The ubiquitin-specific protease 48-elicited deficits in autophagy-lysosomal pathway contribute to the ramification of tauopathy and the pathogenesis of Alzheimer's disease |
2022/08–2023/07 |
NSTC |
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The translational research on the molecular mechanism underlying ubiquitin-specific protease 48-mediated modulation of the proteostasis of amyloid precursor protein in the pathogenesis of Alzheimer's disease |
2021/08–2022/07 |
MoST |
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The molecular mechanism underlying the phosphatidylinositol 4-phosphate 5-kinase type 1α-elicited downregulation of amyloid-b to reduce the susceptibility to Alzheimer's disease |
2020/08–2021/07 |
MoST |
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The molecular mechanism underlying the amyloid-beta-elicited regulation of ErbB2 interactome in Alzheimer’s disease |
2019/08–2020/07 |
MoST |
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The molecular mechanism underlying the amyloid-beta-elicited regulation of ErbB2 expression in Alzheimer’s disease |
2018/08–2019/07 |
MoST |
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The development of ErbB2-targeted immunotherapy for Alzheimer’s disease |
2018/06–2019/05 |
MoST |
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Novel dietary supplement for Alzheimer’s disease |
2018/06–2019/05 |
MoST |
Awards & Prizes :
2018 Science Paper Award in the category of “Biomedical Science & Technology”, Far East Y. Z. Hsu Science and Technology Memorial Foundation.
2018 Research Award, Taiwan Dementia Society.
2007 Young Investigator Awards, Alzheimer’s Drug Discovery Foundation, the 8th International Conference on Alzheimer’s Disease Drug Discovery in New York, NY.
2021/01 – present Associate Editor, Editorial Board, Frontiers in Pharmacology.
2021/09 – present Member, Editorial Board, Journal of Neurogenetics.
