Vaishali Patil

Dr,  KIET School of Pharmacy 

Location: India

Consulting Services

Areas Of Interest

Medical Writing Life Science Pharmaceutical Chemistry Medicinal Chemistry Bioinformatics Computer Aided Drug Design Computational Chemistry Antiviral Agents Antiviral Drugs Anticancer Agents Drug Repurposing Drug Repositioning Preclinical Drug Evaluation Synthetic Chemistry Techniques Green Chemistry Technologies

Professional Narrative

Professional experience of > 17 years in the area of pharmaceutical and life sciences with track record of publications in high impact journals along with numerous book chapters in Academic Press, Springer, NOVA Science Publishers, etc.

 

Employment

Education

PhD, Birla Institute of technology Mesra, India 2014

Referees

Satya P Gupta, BITS-Pilani.

“Ex-Professor”

Publications

  1. Zaki MEA, Al-Hussain SA, Bukhari SNA, Masand VH, Rathore MM, Thakur SD, Patil VM. Exploring the Prominent and Concealed Inhibitory Features for Cytoplasmic Isoforms of Hsp90 Using QSAR Analysis. Pharmaceuticals 2022, 15(3), 303. https://doi.org/10.3390/ph15030303 Impact Factor: 5.863 ISSN: 1424-8247
  2. Cheke, R.S., Patil, V.M., Firke, S.D., et al. Therapeutic outcomes of isatin and its derivatives against multiple diseases: Recent developments in drug discovery. Pharmaceuticals 2022, 15(3), 272 (Impact Factor: 5.863) ISSN: 1424-8247
  3. Singhal, S., Maheshwari, P., Krishnamurthy, P.T., Patil V.M. Drug Repurposing Strategies for Non-Cancer to Cancer Therapeutics. Anti-Cancer Agents in Medicinal Chemistry 2022, 11, 457-479 (Impact Factor: 2.505) ISSN: 1871-5206
  4. Patil, V.M. Role of CSF1R Inhibitor Pexidartinib for the Treatment of Cancer. Russian Journal of Biochemistry 2022, 48, (Impact Factor: 0.796) ISSN: 1068-1620
  5. Cheke, R.S., Patel, H.M., Patil, V.M., Ansari, I.A., et al. Molecular insights into coumarin analogues as antimicrobial agents: Recent developments in drug discovery. Antibiotics 2022 (online ahead of print)
  6. Negi, P., Das, L., Prakash, S., Patil, V.M. Screening of Phytochemicals from Curcuma Longa for their Inhibitory Activity on SARS-CoV-2: An In-Silico Study. Anti-Infective Agents 2022, 20, e190721194860. ISSN (Print): 2211-3525
  7. Patil, V.M., Verma, S., Masand, N. Prospective mode of action of Ivermectin: SARS CoV-2. European Journal of Medicinal Chemistry Reports 2022, 4, 100018. ISSN: 2772-4174
  8. Patil. V.M., Masand, N., Gupta, S.P., Blagg, B.S.J. QSAR studies to predict activity of HSP90 inhibitors. Current Topics in Medicinal Chemistry 2021, 21(25), 2272-2291. DOI: 10.2174/1568026621666211011095858  (Impact Factor 3.295) ISSN: 1568-0266
  9. Ntie-Kang, F., Telukunta K.K., Patil, V.M., et al. Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop. Journal of Cheminformatics 2021, 13, 1-11. (Impact Factor 5.514) ISSN: 1758-2946
  10. Patil, V.M., Gaurav, A., Garg, P., Masand, N. Non-cancer to anti-cancer: investigation of human ether-a-go-go-related gene potassium channel inhibitors as potential therapeutics. Journal of the Egyptian National Cancer Institute 2021, 33,33 DOI: 10.1186/s43046-021-00091-3. ISSN 2589-0409
  11. Patil, V.M., Verma, S., Masand, V., Masand, N. Chromones: Privileged scaffold in anticancer drug discovery. Chemical Biology & Drug Design 2021, 98, 943-953. doi: 10.1111/cbdd.13951 (Impact Factor 2.817) Online ISSN:1747-0285
  12. Cheke R., Patil, V.M. Understanding the dynamics of COVID-19 outbreak: Structure, diagnosis, prevention and treatment. Anti-Infective Agents 2021, 19, Article ID e130621190363 (June 2021).
  13. Patil, V.M., Safe and effective kinase inhibitors for the treatment of gynecological cancers: In silico approach. Current Drug Metabolism, 2021, 22 (7), 537-549 (June 2021) (Impact Factor: 3.731) ISSN: 1389-2002
  14. Negi, P., Cheke, R., Patil, V.M. Src Kinase. Recent advances in pharmacological diversification of Src family kinase inhibitors. Egyptian Journal of Medical & Human Genetics 2021, 22 (1), 1-16. ISSN: 2090-2441
  15. Patil, V.M., Masand, N. Natural databases and tools for anti-cancer drug discovery. Mini Reviews in Medicinal Chemistry 2020, 21(18):2764-2777. DOI : 10.2174/1389557520666200719014828 (Impact Factor: 2.903) ISSN (Print): 1389-5575
  16. Maji, D., Samanta, S., Patil, V.M. In silico ADMET and docking studies of thiazolidinedione-acetic-acid hybrids as antidiabetics with cardioprotection. Letters in Drug Design and Discovery 2020, 17, 1475-1484 (Impact Factor: 1.169)
  17. Gupta, S. P., Sharma, A., Patil, V. M. Molecular Processes Exploited as Drug Targets for Cancer Chemotherapy. Anti-Cancer Agents in Medicinal Chemistry. 2020, 21, 1638-1649. (26 July 2021), DOI : 10.2174/1871520620999201117111139 (Impact Factor: 2.505) ISSN 1871-5206
  18. Negi, P., Prakash, S., Patil, V.M. Structure based drug design approach to identify potential SARS-CoV-2 polymerase inhibitors. Coronaviruses. 2020, DOI : 10.2174/2666796701999201113114545
  19. Kumar, A., Masand, N., Patil, V.M. Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer. Current Chemical Biology. 2020, 15, 69-84. DOI : 10.2174/2212796814999200728185759. ISSN: 1872-3136
  20. Patil, V.M., Singhal, S., Masand, N. A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials. Life Sciences 2020, 254, 117775 (Impact Factor: 5.037)  ISSN 0024-3205
  21. Gupta, S.P., Patil, V.M. Recent studies on design and development of drugs against Alzheimer’s disease (AD) based on inhibition of BACE-1 and other AD-causative agents. Current Topics in Medicinal Chemistry 2020, 20 (13), 1195-1213 DOI: 10.2174/568026620666200416091623 (Impact Factor: 3.402)
  22. Patil, V. M., Anand, P., Bhardwaj, M., Masand, N. Cinnamaldehyde Analogs: Docking Based Optimization, COX-2 Inhibitory in vivo and in vitro Studies. Current Drug Discovery Technology 2020, 17, 154-165. DOI: 10.2174/1570163816666190125153951. ISSN: 1875-6220
  23. Bhardwaj, M., Masand, N., Sahoo, J., Patil, V. M. Risk assessment of cosmetic preservatives using QSAR. International Journal of Quantitative Structure Property Relationship. 2019, 5, 44-62. ISSN: 2379-7487

 

  1. Bhardwaj, M., Patil, V. M., Dhiman, R., Gupta, S. P., Masand, N. Anti-acetylcholinesterase derivatives: a privileged structural framework in drug discovery to treat Alzheimer’s disease. Current Enzyme Inhibition 2019, 15, 1-14. ISSN: 1875-6662
  2. Patil, V. M., Gupta, S. P. Structural flexibility in HCV NS5B polymerase and development of anti-HCV drugs. Current Chemical Biology 2018, 12(1), 65-87.

 

  1. Balasubramanian, K., Patil, V. M. Quantum molecular modeling of hepatitis C virus inhibition through non-structural protein 5B polymerase receptor binding of C5-arylidene rhodanines. Computational Biology and Chemistry 2018, 73, 147-158. (Impact factor: 2.877) ISSN 1476-9271

 

  1. Patil, V. M., Mandal, A., Tomar, S., Masand, N. Phytochemical and pharmacological profile of Diospyros melanoxylon. The Natural Products Journal 2017, 7(4), 267-275. DOI: 10.2174/2210315507666170810155154. ISSN: 0163-3864 
  2. Patil, V. M., Masand, N., Gurukumar, K. R., Chudayeu, M., Gupta, S. P., Samanta, S., Kaushik-Basu, N. Synthesis, in vitro and in silico NS5B Polymerase inhibitory activity of benzimidazole derivatives. Anti-infective Agents in Medicinal Chemistry 2017, 15, 52-56.

 

  1. Patil, V. M., Gupta, S. P., Masand, N. Quantitative structure-activity relationship studies on tyrosine kinase inhibitors. Current Enzyme Inhibition 2017, 13, 139-159.

 

  1. Patil, V. M., Masand, N., Gupta, S. P. GENIUS in silico screening technology for HCV drug discovery. Current Drug Discovery Technology 2016, 13(4), 189-198.

 

  1. Patil, V. M., Das, S., Balasubramanian, K. Quantum chemical and docking insights into bioavailability enhancement of curcumin by piperine in pepper. The Journal of Physical Chemistry A 2016, 120, 3643-3653. DOI: 10.1021/acs.jpca.6b01434 (Impact Factor: 2.781) ISSN 1089-5639
  2. Patil, V.M., Gupta, S.P. Studies on chloride channels and their modulators. Current Topics in Medicinal Chemistry 2016, 16, 1862-1876. DOI: 10.2174/1568026616666151215104302 (Impact Factor: 3.402)
  3. Patil, V. M., Masand, N., Gupta, S. P. HCV inhibitors: Role of compounds from botanical sources. Current Topics in Medicinal Chemistry 2016, 16(12), 1402-1409. DOI: 10.2174/1568026616666151120112802 (Impact Factor: 3.402)
  4. Masand, N., Gupta, S. P., Khosa, R. L., Patil, V. M. Heterocyclic secretase inhibitors for the treatment of Alzheimer’s disease: An overview. Current Nervous System Agents in Medicinal Chemistry 2017, 1, 3-25. DOI: 10.2174/1570159X13666151029105752. ISSN: 1875-6166
  5. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. k Nearest Neighbor-Molecular Field Analysis on human HCV NS5B polymerase inhibitors: 2, 5-Disubstituted Imidazo[4,5-c]pyridines. Medicinal Chemistry Research 2013, 22, 330-339 (Impact Factor: 1.965) ISSN 1054-2523
  6. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. Virtual screening of 1,3-imidazole analogs as potential hepatitis C virus NS5B polymerase inhibitors. Chemical Papers 2013, 67, 236-244 (Impact Factor: 2.097) ISSN 2585-7290
  7. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. 3D-QSAR and Docking Studies on a Series of Benzothiadiazine Derivatives as Genotype 1 HCV Polymerase Inhibitors. Medicinal Chemistry 2012, 8(6), 1099-1107 (Impact Factor: 1.363)
  8. Patil, V. M., Gurukumar, K. R., Chudayeu, M., Gupta, S. P., Samanta, S., Masand, N., Kaushik-Basu, N. Synthesis, in vitro and in silico NS5B Polymerase inhibitory activity of benzimidazole derivatives. Medicinal Chemistry 2012, 8(4), 629-635 (Impact Factor: 1.363)
  9. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. Current Perspective of HCV NS5B Inhibitors: A Review. Current Medicinal Chemistry 2011, 18(36), 5564-5597 (Impact Factor: 3.853) ISSN 0929-8673
  10. Yadav, R. K., Gupta, S. P., Sharma, P. K., Patil, V. M. Recent advances in studies on Hydroxamates as Matrix Metalloproteinase inhibitors: A review. Current Medicinal Chemistry 2011, 18, 1704-1722 (Impact Factor: 3.853) ISSN 0929-8673
  11. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. 3D QSAR kNN-MFA Study on Thiouracil Derivatives as Hepatitis C Virus Inhibitors. Medicinal Chemistry Research 2011, 20: 1616-1621 (Impact Factor: 1.402)  ISSN 1054-2523
  12. Patil, V. M., Gupta, S. P., Samanta, S., Masand, N. 3D QSAR kNN-MFA Study on Thiouracil Derivatives as Hepatitis C Virus Inhibitors. Medicinal Chemistry Research 2010, 19:S45–S149 (Impact Factor:1.402)
  13. Gupta, S. P., Samanta, S., Patil, V. A 3D-QSAR Study on a Series of Benzimidazole Derivatives Acting as Hepatitis C Virus Inhibitors: Application of kNN-Molecular Field Analysis. Medicinal Chemistry 2010, 6, 87-90 (Impact Factor: 2.745) ISSN 1875-6638
  14. Patil, V., Samanta, S., Gupta, S.P. A QSAR study on some series of anti-Hepatitis C (HCV) agents. Letters in Drug Design and Discovery 2010, 7, 139-148 (Impact Factor: 1.15) ISSN: 1875-628X

 

Other Peer Reviewed

  1. Patil, V. M., Masand, N. Use of tobramycin in ventilator associated pneumonia. EC Pharmacology and Toxicology, 2019, 7.7, 631-635

 

  1. Bhagat, K., Patil, V. M., “E-Medicine: An Overview”. EC Pharmacology and Toxicology 2018, 6(10), 899-901.

 

 

  1. Patil, V. M. In silico pharmacology and drug discovery. Annals of Pharmacology and Pharmaceutics 2017, 2(9), 1051. ISSN 2573-6051
  2. Kumar, A., Patil, V. M., Gupta, S. P., Tripathi, A. A QSAR analysis of a series of acridone derivatives acting as HCV inhibitors. Drug Design and Discovery 2014, 1(2) 56-63. ISSN Online: 2349-7777.
  3. Patil, V. M., Gupta, S. P., Masand, N. QSAR analysis of some heterocyclic compounds as HCV NS5B polymerase inhibitors. Journal of Engineering Science and Management Education 2014, 7(III) 166-170. ISSN : 0976-0121 
  4. Patil, V. M., Masand, N., Anand, P. QSAR study on Isatin Analogues Acting as HIV-Reverse Transcriptase Inhibitors. International Journal Drug Design and Discovery 2014, 5(1) 1249-1254.
  5. Upadhyay V., Tiwari, A., Sharma, N., Joshi, H. M., Singh, B., Kalakoti, B. S., Patil, V. M. Rapid determination and standerdisation of Garcinia fruit extract of hydroxycitric acid (HCA) in Garcinia cambogia by HPLC. PharmBIT, XXVII (1) 2013, 1-8.
  6. Anand, P., Patil, V. M., Sharma, V. K., Khosa, R. L., Masand, N. Schiff bases: A review on biological insights. International Journal of Drug Design and Discovery 2012, 3, 851-868.
  7. Patil, V. M., Samanta, S., Gupta, S. P., Kaushik-Basu, N., Masand, N. Docking Directed kNN MFA Study of Pyrimidine Nucleosides as HCV NS5B Inhibitors. International Journal of Drug Design and Discovery 2012, 3(2) 809-813. ISSN :- 2229-5895

 

  1. Patil, V. M., Arora, P. K., Gupta, S. P. Quantitative structure-activity relationship studies on anti-hepatitis viral agents. International Conference & Exhibition Bioequivalence & Bioavailability J. Bioequiv Availab 2010 proceedings (DOI:10.4172/0975-0851.1000067)
  2. Arora, P. K., Patil, V. M., Gupta, S. P. A QSAR study on some series of anti hepatitis B virus (HBV) agents. Bioinformation 2010, 4(9), 417-420. ISSN 0973-2063
  3. Masand, N., Patil, V. M. Designing of Novel Antitubercular agents by 3D QSAR    studies on substituted acid hydrazones. International Journal of Pharmagenesis 2010, 1 (1), 119-125. ISSN: 0976-6154
  4. Kumar, R., Subramanian, A., Masand, N., Patil, V. M. Design and synthesis of substituted pyrrole derivatives as COX-2 inhibitors. Digest Journal of Nanomaterials and Biosciences 2010, 5(3), 667-674.
  5. Patil, V. M., Sinha, R., Jain, J., Masand, N. Synthesis and anticonvulsant activities of small N-substituted pyrrole derivatives. Digest Journal of Nanomaterials and Biosciences 2009, 4(2), 471-477. ISSN 1842-3582
  6. Patil, V. M., Sinha, R., Samanta, S., Masand, N. Synthesis and pharmacological evaluation of N-substituted pyrrole derivatives. PharmBIT 2009, XIX (1), 39-46. ISSN: 0973-6204
  7. Masand, N., Jain, J., Sinha, R., Garg, V. K., Patil, V. Synthesis and biological evaluation of Schiff bases derived from p-dimehtylaminobenzaldehyde. Journal of Cell Tissue and Research 2008, 8 (2), 1431-1435.

 

Books:

  1. Impact of Artificial Intelligence in Healthcare. Edited by Sahoo, J., Patil, V.M., Kumar, P., Jangra, A., Goel, R.  Educreation Publishing, Chhattisgarh, India. 2020. ISBN No. 978-93-89808-22-3. (2020)
  2. Patil, V. M., Gupta, S. P., Masand, N. Hepatitis C Virus: QSAR studies on polymerase inhibitors. ISBN: 978-3-330-08402-5. LAP LAMBERT Academic Publishing. (2019)

 

Chapter in books:

  1. Patil, VM. Chapter 5 - Structure-activity relationship studies on anti-cancer bioactive natural products. In Studies in Natural Products Chemistry. Vol 72, 2022, 147-199. Elsevier https://doi.org/10.1016/B978-0-12-823944-5.00013-2 ISBN: 978-0-12-823944-5, ISSN: 1572-5995
  2. Patil, V. M., Masand, N. Sulfonamides in Clinical Use in Sulfonamides: An Overview. ISBN: 978-1-53618-157-9. NOVA Publications, USA (2021)
  3. Jain YS, Patil VM. Can Mobile Health Technology Improve Health Related Quality of Life of Chronic Disease Patients in Emerging Economies? “Happy Heart” A Randomized Controlled Trial in India. In Book title: Mobile Health: Advances in Research and Applications. ISBN: 978-1-53619-420-3. NOVA Publications, USA (2020)
  4. Patil, V. M., Masand, N. Role of kinases in antiviral therapies.  in A closer look at kinase inhibition. Edited by: Alex Topmson. Nova Science Publishers, USA. ISBN: 978-1-53616-973-7 (2019)
  5. Patil, V.M., Balasubramanian, K., Masand, N. Chapter 14: Dengue Virus Polymerase: A Crucial Target for Antiviral Drug Discovery in Viral Polymerases. Editor: Satya P. Gupta. Elsevier (2019) Pages 387-428 ISBN: 978-0-12-815422-9 Academic Press https://doi.org/10.1016/C2017-0-02951-8

 

  1. Patil, V.M., Masand, N., Gupta, S.P. Chapter 13: Zika Virus Polymerase: Structure, Function and Inhibitors in Viral Polymerases. Editor: Satya P. Gupta. Elsevier (2019)  Pages 357-385 ISBN: 978-0-12-815422-9 Academic Press https://doi.org/10.1016/C2017-0-02951-8
  2. Patil, V. M., Masand, N. (2018) Anticancer Potential of Flavonoids: Chemistry, Biological Activities and Future Perspectives in Studies in Natural Products Chemistry – Vol. 59. Pg 401-430. Editor: Atta-ur-Rahman. Elsevier. ISBN: 9780444641793

 

  1. Patil, V. M., Gupta, S. P. (2017) Studies on picornaviral proteases and their inhibitors. Page no. 263-316 in Viral Proteases and their inhibitors. First Edition,, Ed. Satya Gupta, Elsevier ISBN: 9780128096826

 

  1. Patil, V. M., Gupta, S. P. (2016) Neuraminidase inhibitors: From research tools to drug candidates in Advances in studies on enzyme inhibitors as drugs. Nova science Publishers, Inc., Hauppauge, NY, USA. ISBN: 978-1-53610-504-9

 

  1. Patil, V. M., Gupta, S. P. (2014) Oncolytic viruses and histone deacetylase inhibitors in Cancer-causing viruses and their inhibitors. Ed. Satya Prakash Gupta, CRC Press, Taylor and Francis Group ISBN: 9780429168673

 

  1. Patil, V. M., Masand, N., Gupta, S. P. (2013) Proteases in the management of hepatitis C virus. in Part B: Role of proteases in health and diseases Eds., Sajal Chkraborti and N. S. Dhalla, ISBN 978-1-4614-9232-0 Springer.
  2. Thaler, F., Patil, V. M., Gupta, S. P. (2013) Hydroxamic acids as histone deacetylase inhibitors. Page no. 99-151 in Hydroxamic acids, Ed., S.P. Gupta, 2013, DOI: 10.1007/978-3-642-38111-9 Springer-Verlag Berlin Heidelberg, Basel ISBN: 978-3-642-38111-9
  3. Patil, V. M., Gupta, S. P. (2013) Structure-activity relationship studies of hydroxamic acids as matrix metalloproteinase inhibitors. Page no. 71-98 in Hydroxamic acids, Ed., S.P. Gupta, 2013, DOI: 10.1007/978-3-642-38111-9 Springer-Verlag Berlin Heidelberg, Basel ISBN: 978-3-642-38111-9

 

  1. Patil, V. M., Gupta, S. P. (2012) Quantitative structure-activity relationship studies on sulfonamide-based MMP inhibitors. Page no. 177-208 in Matrix Metalloproteinase Inhibitors, Ed., S.P. Gupta, Experientia Supplementum, 2012, Vol. 103, Edition 1, DOI: 10.1007/978-3-0348-0364-9 Springer-Birkhauser Verlag, Basel ISBN: 978-3-0348-0364-9
  1. Gupta, S. P., Patil, V. M. (2012) Specificity of Binding with Matrix Metalloproteinases. Page no. 35-56 in Matrix Metalloproteinase Inhibitors, Ed., S.P. Gupta, Experientia Supplementum, 2012, Vol. 103, Edition 1, DOI: 10.1007/978-3-0348-0364-9 Springer-Birkhauser Verlag, Basel ISBN: 978-3-0348-0364-9

Grants,Awards and Certifications

Grants :

DST-SERB, India

DBT, India

ICMR, India

Awards & Prizes :

Best Researcher Award at Institute Level

Best Teacher Award by AKTU

Languages

Language Proficiency :

English (Excellent Spoken and Written)

Translation Services :

Marathi to English (Excellent Spoken and Written) to English (Excellent Spoken and Written) to Hindi (Sanskritised Hindustani) (Excellent Spoken and Written) to English (Excellent Spoken and Written) Hindi (Sanskritised Hindustani) to English (Excellent Spoken and Written) to English (Excellent Spoken and Written) to Hindi (Sanskritised Hindustani) (Excellent Spoken and Written) to English (Excellent Spoken and Written) English to English (Excellent Spoken and Written) to English (Excellent Spoken and Written) to Hindi (Sanskritised Hindustani) (Excellent Spoken and Written) to English (Excellent Spoken and Written) Japanese to English (Basic Spoken and Written) to English (Basic Spoken and Written) to Hindi (Sanskritised Hindustani) (Basic Spoken and Written) to English (Basic Spoken and Written)

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