Toussaint Rouamba

Dr,  Clinical Research Unit of Nanoro, Institute for Research in Health Sciences 

Location: Burkina Faso

Consulting Services

Areas Of Interest

Statistic, Biological Bayesian Analysis Forecast, Bayesian Clinical Trial Pharmacoepidemiology Malaria

Professional Narrative

As a Medical Doctor and Public Health Researcher at CNRST/Health Sciences Research Institute, my research activities focus mainly on the analysis of the spatiotemporal dynamics of epidemics (in particular malaria) and of communicable and non-communicable diseases.
As a researcher on quantitative and econometric methods for health research, I have proposed and published (bio)statistical approaches for the analysis of Spatio-temporal clusters, for the assessment of epidemic dynamics, and for the evaluation of the impact of health programs through routinely collected data. In this framework, I proposed approaches to assess the relationships between seasonal transmission, especially of malaria, and different factors such as climatic factors, economic behavior, and population mobility. Furthermore, in the context of the unplanned events of 2019 (health workers' strike) in Burkina Faso, I provide statistical approaches using time-series data (malaria routinely collected data, weather), other survey data (DHS, MICS, SARA, etc.), and other contextual data to address the long term missing data and predict weekly malaria cases for each health district.
In addition, knowing that in most sub-African countries, malaria control activities are implemented at the health-district level (the operational entity of the national health system), and malaria readiness indicators are regionally or nationally representative, I provided an approach for estimating health district-level malaria readiness indicators from survey data designed to provide regionally representative estimates.
Besides my activities on quantitative and econometric methods for health research, I am also in charge of the pharmaco-epidemiology and Drug Safety research axis within the Nanoro Clinical Research Unit (CRUN) and involved in the design and the implementation of the research projects in the Nanoro site.
Regarding my daily activities as responsible for the data management and biostatistics section of the CRUN, I’m in charge of drafting the data management plan and the statistical analysis plan for research projects implemented at the CRUN, or all research projects under the responsibilities of the CRUN (in case of multi countries studies). 
I also provide methodological support for study design. I develop and produce research databases, ensure the quality of the data, clean up the databases and their statistical analysis.

Employment

Education

Ph.D, Université libre de Bruxelles 2020
Master in Public health, Aix Marseille Université 2016
Medical doctor, Université deOuagadougou 2012

Referees

Publications

  1. Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T, Tahita MC, Ido NFA, Yameogo P, Valia D, Millogo A, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Ramos-Lopez F, Cairns M, Provstgaard-Morys S, Aboagye J, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H. Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial. Lancet Infect Dis. 2022 Sep 7:S1473-3099(22)00442-X. doi: 10.1016/S1473-3099(22)00442-X. Epub ahead of print. PMID: 36087586.
  2. Kiemde F, Tinto H, Carter J, Rouamba T, Valia D, Conteh L, Sicuri E, Simmons B, Nour B, Mumbengegwi D, Hailu A, Munene S, Talha A, Aemero M, Meakin P, Paulussen R, Page S, Dijk NV, Mens P, Schallig H. Phase 3 evaluation of an innovative simple molecular test for the diagnosis of malaria in different endemic and health settings in sub-Saharan Africa (DIAGMAL). PLoS One. 2022 Sep 1;17(9):e0272847. doi: 10.1371/journal.pone.0272847. PMID: 36048775; PMCID: PMC9436057.
  3. Rouamba T, Sondo P, Yerbanga IW, Compaore A, Traore-Coulibaly M, Hien FS, Diande NA, Valea I, Tahita MC, Baiden R, Binka F, Tinto H. Prospective observational study to evaluate the clinical and biological safety profile of pyronaridine-artesunate in a rural health district in Burkina Faso. Pharmacol Res Perspect. 2022 Aug;10(4):e00987. doi: 10.1002/prp2.987. PMID: 35855566; PMCID: PMC9297024.
  4. Sondo P, Tahita MC, Ilboudo H, Rouamba T, et al. Boosting the impact of seasonal malaria chemoprevention (SMC) through simultaneous screening and treatment of household members of children receiving SMC in Burkina Faso: a protocol for a randomized open label trial. Arch Public Health. 2022;80(1). doi:10.1186/S13690-022-00800-X
  5. Rouamba T, Ouédraogo E, Barry H, et al. Assessment of Recovery Time, Worsening and Death, among COVID-19 inpatients and outpatients, under treatment with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso. Int J Infect Dis. February 2022. doi:10.1016/j.ijid.2022.02.034
  6. Rouamba T, Barry H, Ouédraogo E, Tahita MC, Yaméogo NV, Poda A, Diendéré AE, Ouedraogo AS, Valea I, Koné AM, Thiombiano C, Traoré I, Tarnagda Z, Sawadogo SA, Gansané Z, Kambiré Y, Sanou I, Barro-Traoré F, Drabo MK, Tinto H; CHLORAZ Study Group. Safety of Chloroquine or Hydroxychloroquine Plus Azithromycin for the Treatment of COVID-19 Patients in Burkina Faso: An Observational Prospective Cohort Study. Ther Clin Risk Manag. 2021 Nov 15;17:1187-1198. doi: 10.2147/TCRM.S330813. PMID: 34815671; PMCID: PMC8604637.
  7. Lingani M, Zango SH, Valéa I, Bonko MDA, Samadoulougou SO, Rouamba T, Tahita MC, Sanou M, Robert A, Tinto H, Donnen P, Dramaix M. Malaria and curable sexually transmitted and reproductive tract coinfection among pregnant women in rural Burkina Faso. Trop Med Health. 2021 Nov 4;49(1):90. doi: 10.1186/s41182-021-00381-5. PMID: 34736524; PMCID: PMC8567650.
  8. Starck T, Bulstra CA, Tinto H, Rouamba T, Sie A, Jaenisch T, Bärnighausen T. The effect of malaria on haemoglobin concentrations: a nationally representative household fixed-effects study of 17,599 children under 5 years of age in Burkina Faso. Malar J. 2021 Oct 23;20(1):416. doi: 10.1186/s12936-021-03948-z. PMID: 34688294; PMCID: PMC8542337.
  9. Sondo P, Bihoun B, Kabore B, Tahita MC, Derra K, Rouamba T, Diallo SN, Kazienga A, Ilboudo H, Valea I, Tarnagda Z, Sorgho H, Lefevre T, Tinto H. Polymorphisme de Plasmodium falciparum et mutations des gènes de résistance Pfcrt et Pfmdr1 dans la zone de Nanoro, Burkina Faso [Polymorphisms in Plasmodium falciparum parasites and mutations in the resistance genes Pfcrt and Pfmdr1 in Nanoro area, Burkina Faso]. Pan Afr Med J. 2021 Jun 10;39:118. French. doi: 10.11604/pamj.2021.39.118.26959. PMID: 34512854; PMCID: PMC8396377.
  10. Sondo P, Tahita MC, Rouamba T, Derra K, Kaboré B, Compaoré CS, Ouédraogo F, Rouamba E, Ilboudo H, Bambara EA, Nana M, Sawadogo EY, Sorgho H, Somé AM, Valéa I, Dahal P, Traoré/Coulibaly M, Tinto H. Assessment of a combined strategy of seasonal malaria chemoprevention and supplementation with vitamin A, zinc and Plumpy'Doz™ to prevent malaria and malnutrition in children under 5 years old in Burkina Faso: a randomized open-label trial (SMC-NUT). Trials. 2021 May 24;22(1):360.
  11. Noori N, Derra K, Valea I, Oron AP, Welgo A, Rouamba T, Boua PR, Somé AM, Rouamba E, Wenger E, Sorgho H, Tinto H, Ouédraogo AL. Patterns of child mortality in rural area of Burkina Faso: evidence from the Nanoro health and demographic surveillance system (HDSS). BMC Public Health. 2021 Jul 19;21(1):1425. doi: 10.1186/s12889-021-11483-4. PMID: 34281547; PMCID: PMC8287796.
  12. Datoo MS, Natama MH, Somé A, Traoré O, Rouamba T, Bellamy D, Yameogo P, Valia D, Tegneri M, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Orindi B, Ramos Lopez F, Flaxman A, Cappuccini F, Kailath R, Elias S, Mukhopadhyay E, Noe A, Cairns M, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H. Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial. Lancet. 2021 May 15;397(10287):1809-1818. doi: 10.1016/S0140-6736(21)00943-0.
  13. Rouamba T, Samadoulougou S, Ouédraogo M, Hien H, Tinto H, Kirakoya-Samadoulougou F. Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017. Malar J. 2021 May 1;20(1):211. doi: 10.1186/s12936-021-03703-4.
  14. Sondo P, Bihoun B, Tahita MC, Derra K, Rouamba T, Nakanabo Diallo S, et al. Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density. Malar J. 2021;20. doi:10.1186/s12936-020-03559-0.
  15. Rouamba T, Samadoulougou S, Bonnechère B, Chiêm B, Kirakoya F. Adequacy of Phenomenological Models in Forecasting Trajectory of the Early Phase of COVID-19 Outbreak : Application to Burkina Faso Data. Int J Stat Anal. 2020;1:1–12
  16. Natama HM, Toussaint R, Bazié DLC, Samadoulougou S, Coulibaly-Traoré M, Tinto H, et al. Prevalence and factors associated with carriage of Pfmdr1 polymorphisms among pregnant women receiving intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and artemether-lumefantrine for malaria treatment in Burkina Faso. Malar J. 2020;19. doi:10.1186/s12936-020-03473-5
  17. Zango SH, Lingani M, Valea I, Samadoulougou OS, Bihoun B, Rouamba T, et al. Malaria and curable sexually transmitted infections in pregnant women: A two-years observational study in rural Burkina Faso. PLoS One. 2020;15:e0242368. doi:10.1371/journal.pone.0242368.
  18. Rouamba T, Samadoulougou S, Kirakoya-Samadoulougou F. Addressing challenges in routine health data reporting in Burkina Faso through Bayesian spatiotemporal prediction of weekly clinical malaria incidence. Sci Rep. 2020 Oct 6;10(1):16568..
  19. Sondo P, Derra K, Rouamba T, Nakanabo Diallo S, Taconet P, Kazienga A, Ilboudo H, Tahita MC, Valéa I, Sorgho H, Lefèvre T, Tinto H. Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso. Parasit Vectors. 2020 Aug 20;13(1):427. doi: 10.1186/s13071-020-04302-z.
  20. Rouamba T, Sondo P, Derra K, Nakanabo-Diallo S, Bihoun B, Rouamba E, Tarnagda Z, Kazienga A, Valea I, Sorgho H, Pagnoni F, Samadoulougou-Kirakoya F, Tinto H. Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso. Drug Des Devel Ther. 2020; 14:1507-1521. DOI:10.2147/DDDT.S224857
  21. Rouamba T, Samadoulougou S, Tinto H, Alegana VA, Kirakoya F. Spatial and Spatio-temporal Epidemiology Severe-malaria infection and its outcomes among pregnant women in Burkina Faso health-districts : Hierarchical Bayesian space-time models applied to routinely-collected data from 2013 to 2018. Spat Spatiotemporal Epidemiol. 2020;33:100333.
  22. Rouamba T, Samadoulougou S, Tinto H, Alegana VA, Kirakoya-Samadoulougou F. Bayesian Spatiotemporal Modeling of Routinely Collected Data to Assess the Effect of Health Programs in Malaria Incidence During Pregnancy in Burkina Faso. Sci Reports 2020 101. 2020;10:1–15.
  23. Ouédraogo M, Rouamba T, Samadoulougou S, Kirakoya-Samadoulougou F. Effect of Free Healthcare Policy for Children under Five Years Old on the Incidence of Reported Malaria Cases in Burkina Faso by Bayesian Modelling: “Not only the Ears but also the Head of the Hippopotamus.” Int J Environ Res Public Health. 2020;17:417. doi:10.3390/ijerph17020417.
  24. Tinto H, Rouamba T. Drug safety in Burkina Faso. In: Al-Worafi Y, editor. Drug Safety in Developing Countries. Elsevier; 2020. p. 569–84. doi:10.1016/B978-0-12-819837-7.00040-6
  25. Rouamba T, Sondo P, Yerbanga IW, Compaore A, Akweongo P, Baiden R, et al. High adherence level to artemisinin-based combination therapies in rural settlement 11 years after their introduction in the health system , Nanoro , Burkina Faso. Patient Prefer Adherence. 2019;13:371–80.
  26. Rouamba T, Nakanabo-Diallo S, Derra K, Rouamba E, Kazienga A, Inoue Y, et al. Socioeconomic and environmental factors associated with malaria hotspots in the Nanoro demographic surveillance area, Burkina Faso. BMC Public Health. 2019;19:1–14.
  27. Rouamba T, Kpoda H, Valea I, et al. Safety of antimalarial drug use during early pregnancy in Bobo Dioulasso: Examining low birth weight and congenital malformations as potential adverse outcomes. In: Tropical Medicine and International Health, 2017. Vol 22. Blackwell Science; 2017:95.
  28. Rouamba T, Valea I, Bognini JD, et al. Safety Profile of Drug Use During Pregnancy at Peripheral Health Centres in Burkina Faso: A Prospective Observational Cohort Study. Drugs - Real World Outcomes. 2018;5(3):193-206. doi:10.1007/s40801-018-0141-1

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French (Excellent Spoken and Written)

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