Raffaele Pezzani

BSc, MD, PhD,  Dept. of Medicine (DIMED), University of Padova 

Location: Italy

Consulting Services

Areas Of Interest

Phytotherapy Endocrinology Nutraceuticals Cancer

Professional Narrative

2015-to-now: Principal Investigator, Phytotherapy lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova

2018-07-23 Iscritto all’Ordine dei Medici e Chirurghi della Provincia Autonoma di Trento (Medical Order of Trento, Italy), n° 4599.

2018-07-10 Abilitazione all’esercizio della professione medica, Padova, Italy (Authorization to the practice of medical profession in Italy/Europe)

2017-12-15 Master Degree in Medicine and Surgery at the University of Padova, Italy.

2008-09-30 Patentee with “Hypodermic needle with safety device" in collaboration with the University of Padova, code PD2008A000275 (deposit 2008-09-30).

2008-10-07 PhD in Neuroscience at the University of Padova, School of Medical, Clinical and Experimental Sciences (20th cycle).

2001-11-30 Esame di stato per l’abilitazione all’esercizio della professione di biologo, Università degli Studi di Padova (State examination licensing for the practice of the profession of Biologist, at the University of Padova, Italy)

2001-07-09 Master Degree in Biological Sciences at the University of Padova, Italy.

 

Employment

principal investigator, university of padova 2015

Education

PhD in Neurosciences, University of Padova 2008

Referees

Javad Sharifi-rad, Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador and Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

“Prof”

Miquel Martorell, Department of Nutrition and Dietetics, Faculty of Pharmacy and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile..

“Prof”

Publications

  1. Myricetin: A comprehensive review on its biological potentials. Imran et al. Food Science and Nutrition 2021, 9, 5854– 5868. https://doi.org/10.1002/fsn3.2513

 

  1. An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes. Martorell et al. EBCAM 2021, 3313419. doi: 10.1155/2021/3313419

 

 

  1. Plant Natural Compounds in the Treatment of Adrenocortical Tumors. Manso et al. Int J Endocrinol 2021, 5516285. doi: 10.1155/2021/5516285

 

  1. Cocoa and cocoa bean shells role in human health: An updated review. Cinar et al. Journal of Food Composition and Analysis 2021, 103, 104115. doi: 10.1016/j.jfca.2021.104115.

 

  1. Clinical applications of artificial intelligence and machine learning in cancer diagnosis: looking into the future. Iqbal et al. Cancer Cell Int. 2021, 21(1):270. doi: 10.1186/s12935-021-01981-1.

 

  1. The wonderful activities of Mentha genus: not only antioxidant
    properties. Tafrihi et al. Molecules. 2021, 20;26(4):1118. doi: 10.3390/molecules26041118.

 

  1. Curcumin nanoformulations for antimicrobial and wound healing purposes. Salehi et al. Phytotherapy research. 2021 Feb 15; 1– 13 Doi 10.1002/ptr.6976

 

  1. Immunophenotypical characterization of paraneoplastic neurological syndrome patients: a multicentric study. Lorusso et al. Journal of Biosciences. 2021;46;13.  Doi 10.1007/s12038-020-00128-0 

 

  1. Acute effect of chili consumption on thermogenesis and glycemic response post oral glucose load in men. Ávila-Seguel et al. Current Topics in Nutraceutical Research. 2021 19; 1–7. Doi: 10.37290/ctnr2641-452X.19:1–7

 

  1. A comprehensive review on ethnobotanical, phytochemical and pharmacological aspects of the genus Dorema. Mottaghipisheh et al. Phytochemistry Reviews. 2021 05 January 2021, doi: 10.1007/s11101-020-09727-z.

 

  1. Editorial to the Special Issue "Biological and Pharmacological Activity of Plant Natural Compounds". Pezzani et al. Molecules. 2020 Dec 25;26(1):E63. doi: 10.3390/molecules26010063.

 

  1. Multivesicular Liposome (Depofoam) in Human Diseases. Salehi et al. Iran J Pharm Res. 2020 19(2):9-21. doi: 10.22037/ijpr.2020.112291.13663.

 

  1. Vicia plants - A comprehensive review on chemical composition and phytopharmacology. Salehi et al. Phytother Res. 2020 1– 20. doi: 10.1002/ptr.6863.   

 

  1. In vitro evaluation of different organic matrices used to modulate silicon bioavailability. Tedesco et al. The FASEB Journal, 2020 34: 12229–12238. doi: 10.1096/fj.202000060RR.  

 

  1. Phytochemical and pharmacological properties of asperuloside, a systematic review. Manzione et al. Eur J Pharmacol 2020 883:173344. doi:10.1016/j.ejphar.2020.173344

 

  1. Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study. Cavedon et al. Int J Endocrinol. 2020 May 28;2020:4802739. doi: 10.1155/2020/4802739

 

  1. Statins reduce intratumor cholesterol affecting adrenocortical cancer growth. Trotta et al. Mol Cancer Ther. 2020 Sep;19(9):1909-1921. doi: 10.1158/1535-7163.MCT-19-1063.

 

  1. Plant natural products with anti-thyroid cancer activity. Sharifi-rad et al. Fitoterapia. 2020 May 28:104640. doi: 10.1016/j.fitote.2020.104640

 

  1. Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice. Bezerra et al. Molecules. 2020 May 7;25(9): E2181. doi: 10.3390/molecules25092181.

 

  1. LncRNAs as Potential Therapeutic Targets in Thyroid Cancer. Javed et al. Asian Pac J Cancer Prev. 2020 Feb 1;21(2):281-287. doi: 10.31557/APJCP.2020.21.2.281.

 

  1. Anticancer Effects of Wild Mountain Mentha longifolia Extract in Adrenocortical Tumor Cell Models. Patti et al. Frontiers in Pharmacology 2020; 10;1647 doi: 10.3389/fphar.2019.01647

 

  1. Sisymbrium officinale, the Plant of Singers: A Review of Its Properties and Uses. Zorzan et al. Planta Med. 2020 Feb 4 86(5):307-311. doi: 10.1055/a-1088-9928.

 

  1. Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer. Sharifi-Rad et al. Molecules. 2020 Jan 22;25(3). pii: E467. doi: 10.3390/molecules25030467.

 

  1. Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine. Salehi et al. Biomolecules. 2019 Nov 23;9(12). pii: E773.

 

  1. Circulating miRNA Expression Profiling in Primary Aldosteronism. Decmann et al. Front Endocrinol (Lausanne). 2019, 10:739. doi: 10.3389/fendo.2019.00739

 

  1. The effects of mitotane and 1α,25-dihydroxyvitamin D3 on Wnt/beta-catenin signaling in human adrenocortical carcinoma cells. Rubin et al. J Endocrinol Invest. 2019 Oct 5 43(3):357-367. doi: 10.1007/s40618-019-01127-1

 

  1. Bioactive Compounds and Health Benefits of Artemisia Species. Nigam et al. Nat Prod Comm. 2019 July 24, 14, 7. doi: https://doi.org/10.1177/1934578X19850354

 

  1. Biological Effects of EF24, a Curcumin Derivative, Alone or Combined with Mitotane in Adrenocortical Tumor Cell Lines. Bertazza et al. Molecules. 2019 Jun 12;24(12). pii: E2202.

 

  1. Wnt Signaling: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma. Javed et al. Asian Pac J Cancer Prev. 2019 Apr 29;20(4):995-1003

 

  1. Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective. Pezzani et al. Medicina (Kaunas). 2019 Apr 17;55(4). pii: E110. doi: 10.3390/medicina55040110

 

  1. Investigation of the molecular reactivity of bioactive oxiranylmethyloxy anthraquinones. Ribaudo et al. Arch Pharm (Weinheim). 2019, Apr 18:e1900030. doi:10.1002/ardp.201900030

 

  1. Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients. Pezzani et al. International Journal of Endocrinology, 2019:9421079. https://doi.org/10.1155/2019/9421079

 

  1. Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model. Zorzan et al. Journal of Functional Foods 2019 Jan 15 54(8):92-97, doi:10.1016/j.jff.2019.01.007

 

  1. Effects of point mutations in the binding pocket of the mouse major urinary protein MUP20 on ligand affinity and specificity. Ricatti et al. Sci Rep. 2019 Jan 22;9(1):300. doi: 10.1038/s41598-018-36391-3.

 

  1. The Therapeutic Potential of Naringenin: A Review of Clinical Trials. Salehi et al. Pharmaceuticals (Basel) 2019 Jan 10;12(1). pii: E11. doi: 10.3390/ph12010011.

 

  1. MicroRNA expression profiling in adrenal myelolipoma. Decmann A et al. J Clin Endocrinol Metab. 2018 Jun 21 ;103(9):3522-3530. doi: 10.1210/jc.2018-00817.

 

  1. New targeted therapies for adrenocortical carcinomas. Manso and Pezzani, Minerva Endocrinol. 2018 May 28 44(1):70-81. doi: 10.23736/S0391-1977.18.02860-2.

 

  1. Relationship between sodium, pentraxin-3 and aldosterone in inflammation and cardiovascular risk. Armanini et al. J Clin Hypertens (Greenwich). 2018 Apr 27 ;20(5):932-934. doi: 10.1111/jch.13298.

 

  1. EF24 (a Curcumin Analog) and ZSTK474 Emphasize the Effect of Cabozantinib in Medullary Thyroid Cancer. Bertazza et al. Endocrinology. 2018 Jun 1;159(6):2348-2360. doi: 10.1210/en.2018-00124.

 

  1. Phytotherapeutics in cancer invasion and metastasis. Salehi et al. Phytother Res. 2018 32(8):1425-1449. doi: 10.1002/ptr.6087.

 

  1. Programmed Cell Death, from a Cancer Perspective: An Overview. Mishra et al. Mol Diagn Ther. 2018 Jun;22(3):281-295. doi: 10.1007/s40291-018-0329-9.  

 

  1. The natural history of autoimmune Addison's disease with a non-classical presentation: a case report and review of literature. Manso et al. Clin Chem Lab Med. 2018 May 24;56(6):896-900. doi: 10.1515/cclm-2017-1108.  

 

  1. Adrenocortical carcinoma: current knowledge. Pezzani Minerva Endocrin. 2019 June; 44(2):232.

 

  1. Crude extract of Origanum vulgare L. induced cell death and suppressed MAPK and PI3/Akt signaling pathways in SW13 and H295R cell lines. Rubin et al. Nat Prod Res. 2018 Jan 15:1-4.

 

  1. Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors Perge et al. Endocrine 2018, 59(2):280-287 doi: 10.1007/s12020-017-1506-z

 

  1. Exosomal hsa-miR-483-5p and hsa-miR-101 are potential minimally invasive biomarkers of adrenocortical carcinoma Perge et al. Endocrine Abstracts 2017, 49 GP3  doi:10.1530/endoabs.49.GP3

 

  1. Bioactivities of Origanum vulgare L.: an update Pezzani et al. Phytochem Rev 2017 16: 1253.

 

  1. Adrenocortical Carcinoma: in the Search for a Pre-Operative Biomarker Pezzani R. Acta Endo (Buc) 2017 13: 340-341.

 

  1. Evaluation and diagnostic potential of circulating extracellular vesicle-associated microRNAs in adrenocortical tumors Perge et al. Scientific reports 2017:7:5474.

 

  1. Sodium intake, sodium excretion, and cardiovascular risk: involvement of genetic, hormonal, and epigenetic factors, Armanini et al. J Clin Hypertens (Greenwich). 2017:19:650-652.

 

  1. Antiproliferative activity of Juglone derivatives on rat glioma, Pavan et al. Nat Prod Res. 2017;31:632-638.

 

  1. Investigation of N-cadherin/beta catenin expression in adrenocortical tumors Rubin et al. Tumor Biol. 2016;37:13545-13555.

 

  1. Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors. Barollo et al. PLoS One. 2016 May 25; 11:e0156044.

 

  1. The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line. Pezzani et al. Invest New Drugs. 2016; 34:531-40.

 

  1. Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors. Rubin et al Cancer Invest. 2015;33:526-31.

 

  1. Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors. Ribaudo et al. Fitoterapia. 2015;105:132-8.

 

  1. Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. Bertazza et al J Cell Mol Med. 2015;19:2244-52.

 

  1. New naphthoquinone derivatives against glioma cells. Redaelli et al. Eur J Med Chem. 2015;96:458-66.

 

  1. The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K/Akt signaling pathways. Barollo et al. Invest New Drugs. 2014;32:626-35.

 

  1. Aurora kinases inhibitors Vx-680, SNS314 and ZM447439 in adrenocortical tumors. Pezzani et al. Endocrine Abstracts 2014, 35, P536. doi:10.1530/endoabs.35.P536

 

  1. New drugs switching off Wnt/β-catenin signaling in adrenocortical tumor cells. Rubin et al. Endocrine Abstracts 2014, 35, P12. doi:10.1530/endoabs.35.P12

 

  1. Prevalence, tumorigenic role, and biochemical implications of rare BRAF alterations. Barollo et al. Thyroid. 2014;24:809-19.

 

  1. The antiproliferative effects of ouabain and everolimus on adrenocortical tumor cells. Pezzani et al. Endocr J. 2014;61:41-53.

 

  1. Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer. Barollo et al. Exp Clin Endocrinol Diabetes. 2013;121:546-50.

 

  1. Investigation of β-catenin, N-cadherin, and E-cadherin expression in adrenocortical tumors. Rubin et al. Endocrine Abstracts 2013, 32, P20.doi: 10.1530/endoabs.32.P20

 

  1. Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models. Mariniello et al. Endocr Relat Cancer. 2012;19:527-39.

 

  1. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. Monticone et al. J Clin Endocrinol Metab. 2012;97:E1567-72. 

 

  1. Cardiomyopathy in patients with POMT1-related congenital and limb-girdle muscular dystrophy. Bello et al.  Eur J Hum Genet. 2012;20:1234-9.

 

  1. BRAF(K601E) mutation in a patient with a follicular thyroid carcinoma. Pennelli et al. Thyroid. 2011; 21 :1393-1396.

 

  1. Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study. Mercuri et al. Neurology. 2009;72:1802-9.

 

  1. POMT1 and POMT2 mutations in CMD patients: a multicentric Italian study. Messina et al. Neuromuscul Disord. 2008;18:565-71.

 

  1. Neurological complications of celiac disease and autoimmune mechanisms: preliminary data of a prospective study in adult patients. Briani et al. Ann N Y Acad Sci. 2005;1051:148-55.

 

  1. Immunological features of neurological paraneoplastic syndromes. Lorusso et al. Int J Immunopathol Pharmacol. 2004;17:135-44.

 

1. The spectrum of antineuronal autoantibodies in a series of neurological patients. Vianello et al. J Neurol Sci. 2004;220:29-36

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Language Proficiency :

English (Excellent Spoken and Written) Italian (Excellent Spoken and Written)

Translation Services :

English to Italian (Excellent Spoken and Written)

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