Dr. Spite is an Associate Professor at Harvard Medical School and a Lead Investigator in the Center for Experimental Therapeutics and Reperfusion Injury (CETRI), Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital. He is also the Co-Director of the CETRI metabolipidomics-core. His research focuses on the role of lipid mediators in inflammation. As a postdoctoral fellow with Dr. Charles Serhan, he contributed to the structural elucidation of lipid mediators that promote the resolution of acute inflammation (i.e., resolvin D2 and maresin 1) and maintains an active independent research program that seeks to understand the role of these “pro-resolving mediators” in innate immunity, vascular biology and tissue repair.

His group is also interested in understanding whether defects in pro-resolution pathways contribute to chronic inflammation in cardiovascular and metabolic disease, and whether pro-resolving mediators could be used as templates to develop novel therapeutics for chronic inflammatory diseases.