Maria Longhi
Associate Professor of Anaesthesia, Harvard Medical
Location: United States
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Dr. Maria Serena Longhi's research aims at defining how immune responses are regulated in chronic inflammatory statuses and in autoimmune disorders, including inflammatory bowel disease and autoimmune hepatitis. Dr. Longhi aims to identify key mechanisms that lead to functional impairment of regulatory T cells (Treg), a lymphocyte subset central to immunotolerance maintenance. Multiple mechanisms contribute to Treg impairment in patients with autoimmune hepatitis. As part of these investigations Dr. Longhi's laboratory is currently defining the alterations in AhR signaling pathways leading to Treg dysfunction in this autoimmune condition.
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