Li Chai
Associate Professor, Pathology, Harvard Medical School Associate Director of Adult Transfusion Medicine, Pathology, Brigham And Women's Hospital
Location: United States
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Dr. Chai graduated from Shandong Medical University, China. Her research is focused on the homeotic gene family SALL in human development, tumorigenesis and hematopoiesis. SALL gene family is the mammalian homologue of Drosophila gene Spalt (sal). In Drosophila, sal mutation can lead to the incomplete separation of the head and trunk of the fly. In human, heterogenous mutation of SALL1 cause Townes-Brock Syndrome with renal, cardiac, digit, genital malformation. Heterogenous mutation of SALL4 in human is associated with Okihiro Syndrome with limitation of eye abduction, deafness and digit malformation. SALL2 is a potential tumor suppressor gene in ovary carcinogenesis and may play a role in hematopoiesis and leukemogenesis.
Her research areas range from characterization of SALL family gene structure, transcriptional regulation, tissue distributions to its function study by generating knock-out or transgene mouse model.
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