The research of Keith A. Josephs, M.D., focuses on the relationship between clinical diagnoses, neuroimaging and the neuropathological underpinnings accounting for neurodegenerative diseases. Neurodegenerative diseases of particular interest include progressive supranuclear palsy, corticobasal degeneration, apraxia of speech, semantic dementia, primary progressive aphasia and posterior cortical atrophy.

Dr. Josephs is currently the principal investigator of multiple National Institutes of Health grants and foundation grants and co-investigator of multiple foundation grants.

Focus areas

• Progressive apraxia of speech
• Progressive supranuclear palsy
• Alzheimer's disease
• Frontotemporal dementia
• Semantic dementia

Significance to patient care

Dr. Josephs' research aims to identify new ways to diagnosis and treat patients with devastating neurodegenerative diseases. Dr. Josephs and his team recently identified a new link between a protein known as TDP-43 and Alzheimer's disease. This breakthrough will lead to new approaches aimed at the treatment of Alzheimer's disease. Coverage of Dr. Josephs' work has been featured in major media outlets such as Bloomberg News and the Minneapolis StarTribune.