Johannes Schlondorff
Assistant Professor of Medicine , Beth Israel Deaconess Medical Center
Location: United States
Consulting Services
Areas Of Interest
Professional Narrative
The overarching goal of the Schlondorff laboratory's research efforts is to understand the normal function of podocytes and their role in maintaining the glomerular filtration barrier. Impaired podocyte function and podocyte loss are thought to be central to the development and progression of proteinuric kidney diseases such as focal segmental glomerulosclerosis (FSGS) and diabetic kidney disease. Through collaborations with Dr. Pollak’s lab, we have focused on developing a mechanistic understanding of the effect of disease-causing human mutations on podocyte function, with the goal of identifying common pathways perturbed in both rare and common kidney diseases. These efforts have largely focused on examining the role of three genes, TRPC6, ACTN4, and INF2, in which mutations are known to cause FSGS. The lab utilizes an array of techniques spanning protein biochemistry, cell biology, and genetically engineered mouse models in our efforts.
Employment
Education
Referees
Publications
Grants,Awards and Certifications
Grants :
No Grants Mentioned !!
Awards & Prizes :
