George Varghese

Professor,  Infectious Diseases, Christian Medical College, Vellore 

Location: India

Consulting Services

Case Consulting Research Consulting Career Advice and Mentoring Conferences

Areas Of Interest

Infectious Diseases Specialties Global Health Tropical Medicine Clinical Research Protocols Emerging Infectious Diseases Tuberculosis Antimicrobial Drug Resistance Rickettsial Diseases Scrub Typhus Anthrax Melioidosis Brucellosis Leptospirosis Emerging Infectious Disease Fungal Infection

Professional Narrative

George M. Varghese is a Professor of Infectious Diseases at the Christian Medical College, Vellore, India, where he underwent his undergraduate and postgraduate medical training. With over three decades of experience as a clinician, teacher and researcher, George has extensive training in infectious diseases and tropical medicine in many centres of excellence, such as the London School of Hygiene & Tropical Medicine and Wayne State University, USA.

George has been an expert in infectious diseases and global health and currently serves on several national and international committees, including the Trustee of the Royal Society of Tropical Medicine & Hygiene, UK expert committee of the Indian Council of Medical Research and Governing Council of the Clinical Infectious Diseases Society. 

He has been honoured with several recognitions, such as the Guerrant International Young Investigator Award by the Infectious Disease Society of America, the MG Alexander Award in Tropical Medicine by the Clinical Infectious Diseases Society and the Linnaeus-Palme Visiting Professor by the Swedish Government for the pioneering work in rickettsial infections. Besides these recognitions, George is a Fellow of the Infectious Diseases Society of America and a Fellow of the Royal College of Physicians.

George is passionate about translating research from bench to bedside at the community level to combat infectious diseases. Recently, he was awarded a Senior Fellowship by the Wellcome Trust DBT Alliance.

Employment

Education

MBBS, Christian Medical College, Vellore, India 1995
MD, DNB, Christian Medical College, Vellore, India 2001
DTMH, London School of Hygiene & Tropical Medicine 2006
Fellowship in Infectious Diseases, Wayne State University, USA 2008

Referees

Publications

  1. Kundavaram APP, Selvan S, Raja V, Mathiyalagan P, Kanagarajan R, Reddy NP, Rajendiran N, Hazra D, Gunasekaran K, Moorthy M, Lenin A, Mathew D, Iyyadurai R, Varghese GM, Dj C, Joy M, Peter JV. Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India. BMJ Open. 2022 Nov 21;12(11):e062724. doi: 10.1136/bmjopen-2022-062724
  2. Manesh A, Devasagayam E, Bhanuprasad K, Mathew SK, Karthik R, Mathew BS, Varghese GM. Efficacy of Crushed Delayed-Release Posaconazole Tablets in Rhino-Orbito-Cerebral Mucormycosis. Antimicrob Agents Chemother. 2022 Nov 15:e0108522. doi: 10.1128/aac.01085-22.
  3. Kundavaram APP, Selvan S, Raja V, Mathiyalagan P, Kanagarajan R, Reddy NP, Rajendiran N, Hazra D, Gunasekaran K, Moorthy M, Lenin A, Mathew D, Iyyadurai R, Varghese GM, Dj C, Joy M, Peter JV. Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India. BMJ Open. 2022 Nov 21;12(11):e062724. doi: 10.1136/bmjopen-2022-062724.
  4. Chandna A, Mahajan R, Gautam P, Mwandigha L; PRIORITISE Study Investigators, Kumar P, Varghese GM, Koshiaris C, Lubell Y, Burza S. Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study. Open Forum Infect Dis. 2022 Oct 6;9(10):ofac526. doi: 10.1093/ofid/ofac526.
  5. Kaswala C, Schmiedel Y, Kundu D, George MM, Dayanand D, Devasagayam E, Manesh S A, Kumar SS, Michael JS, Ninan MM, Chacko G, Zachariah A, Sathyendra S, Hansdak SG, Iyadurai R, Christopher DJ, Gupta R, Karthik R, Abraham OC, Varghese GM. Accuracy of Gene Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: A retrospective cohort study. Int J Infect Dis. 2022 Jul 7:S1201-9712(22)00410-6. doi: 10.1016/j.ijid.2022.07.016.
  6. Cherian LM, Varghese L, Rupa V, Bright RR, Abraham L, Panicker R, R N, Peter J, Nayak A, Shyam A, Varghese GM, Manesh A, Karuppusami R, George K, George T, Lenin A, Hansdak SG, I R, Michael JS, Ninan M, Thomas M, Kurian R, Mammen S, Kurien R. Rhino-orbito-cerebral mucormycosis: patient characteristics in pre-COVID-19 and COVID-19 period. Rhinology. 2022 Sep 23. doi: 10.4193/Rhin22.099.
  7. Solaimalai D, Gupta A, George L, Manesh A, Karthik R, Sathishkumar D, Peter CVD, Varghese GM, Pulimood SA, Kannangai R, Prakash JA. Upward trends of syphilis in the non-pregnant adults: A six-year report on clinical and epidemiological profile of syphilis from a tertiary care center, India. Front Public Health. 2022 Jul 26;10:908591. doi: 10.3389/fpubh.2022.908591.
  8. Goyal-Honavar A, Gupta A, Manesh A, Varghese GM, Edmond Jonathan G, Prabhu K, Chacko AG. A prospective evaluation of postoperative fever in adult neurosurgery patients in the COVID-19 era. J Clin Neurosci. 2022 Jul 4;103:26-33. doi: 10.1016/j.jocn.2022.06.024.
  9. Kundu D, Gautam P, Dayanand D, Gunasekaran K, Manesh A, Sebastian M, Abhilash KPP, Zachariah A, George T, Sathyendra S, Hansdak SG, Abraham OC, Iyadurai R, Thangakunam B, Gupta R, Karthik R, Moorthy M, Varghese GM. The role and diagnostic accuracy of serology for COVID-19. BMC Infect Dis. 2022 Apr 19;22(1):390. doi: 10.1186/s12879-022-07361-y.
  10. Ramalingam VV, Fletcher GJ, Kasirajan A, Demosthenes JP, Rupali P, Varghese GM, Pulimood SA, Rebekah G, Kannangai R. Can in-house HIV-2 viral load assay be a reliable alternative to commercial assays for clinical and therapeutic monitoring? Curr HIV Res. 2022 Jun 9. doi: 10.2174/1570162X20666220609155237.
  11. Muthu V, Agarwal R, Patel A, Kathirvel S, Abraham OC, Aggarwal AN, Bal A, Bhalla AS, Chhajed PN, Chaudhry D, Garg M, Guleria R, Krishnan RG, Kumar A, Maheshwari U, Mehta R, Mohan A, Nath A, Patel D, Rudramurthy SM, Saxena P, Sethuraman N, Singhal T, Soman R, Thangakunam B, Varghese GM, Chakrabarti A. Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India. Lancet Infect Dis. 2022 Apr 4:S1473-3099(22)00124-4. doi: 10.1016/S1473-3099(22)00124-4.
  12. Ninan MM, Rupali P, Varghese GM, Shalini EB, Venkatesh K, Jesudason MR, Rebekah G, Michael JS. Xpert Ultra in diagnosing extrapulmonary TB: accuracy and trace calls. Int J Tuberc Lung Dis. 2022 May 1;26(5):441-445.
  13. Karuppusamy KV, Demosthenes JP, Venkatesan V, Christopher AC, Babu P, Azhagiri MK, Jacob A, Ramalingam VV, Rangaraj S, Murugesan MK, Marepally SK, Varghese GM, Srivastava A, Kannangai R, Thangavel S. The CCR5 Gene Edited CD34+CD90+ Hematopoietic Stem Cell Population Serves as an Optimal Graft Source for HIV Gene Therapy. Front Immunol. 2022 Mar 14;13:792684. doi: 10.3389/fimmu.2022.792684.
  14. Chandna A, Mahajan R, Gautam P, Mwandigha L, Gunasekaran K, Bhusan D, Cheung ATL, Day N, Dittrich S, Dondorp A, Geevar T, Ghattamaneni SR, Hussain S, Jimenez C, Karthikeyan R, Kumar S, Kumar S, Kumar V, Kundu D, Lakshmanan A, Manesh A, Menggred C, Moorthy M, Osborn J, Richard-Greenblatt M, Sharma S, Singh VK, Singh VK, Suri J, Suzuki S, Tubprasert J, Turner P, Villanueva AMG, Waithira N, Kumar P, Varghese GM, Koshiaris C, Lubell Y, Burza S. Facilitating safe discharge through predicting disease progression in moderate COVID-19: a prospective cohort study to develop and validate a clinical prediction model in resource-limited settings. Clin Infect Dis. 2022 Mar 21:ciac224. doi: 10.1093/cid/ciac224.
  15. Abhilash KPP, Mathiyalagan P, Krishnaraj VRK, Selvan S, Kanagarajan R, Reddy NP, Rajendiran N, Hazra D, Gunasekaran K, Moorthy M, Jasmine S, Davis JP, George T, George K, Varghese GM, Rupali P, Barney Isaac TJ, Gupta R, Pichamuthu K, Joy M, Jayaseelan L, Mathews P, Peter JV. Impact of prior vaccination with CovishieldTM and Covaxin® on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study. Vaccine. 2022 Mar 18;40(13):2107-2113. doi: 10.1016/j.vaccine.2022.02.023.
  16. Dayanand D, Irudhayanathan I, Kundu D, Manesh A, Abraham V, Abhilash KP, Chacko B, Moorthy M, Samuel P, Peerawaranun P, Mukaka M, Joseph J, Sivaprakasam M, Varghese GM. Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention. Int J Infect Dis. 2021: S1201-9712(21)01255-8. doi: 10.1016/j.ijid.2021.12.356.
  17. S D, S TD, Gupta R, Varughese S, Varghese GM, George B, Michael JS. Effectiveness of a real-time PCR for diagnosis of Pneumocystis pneumonia in immunocompromised patients - Experience from a tertiary care center, India. J Mycol Med. 2021; 32(2): 101241. doi: 10.1016/j.mycmed.2021.101241.
  18. Bhanuprasad K, Manesh A, Devasagayam E, Varghese L, Cherian LM, Kurien R, Karthik R, Deodhar D, Vanjare H, Peter J, Michael JS, Thomas M, Samuel P, Varghese GM. Risk Factors Associated with the Mucormycosis Epidemic During the COVID-19 Pandemic. Int J Infect Dis. 2021 Aug 24:S1201-9712(21)00670-6. doi: 10.1016/j.ijid.2021.08.037.
  19. Nair M, Zeegers MP, Varghese GM, Burza S. India's National Action Plan on Antimicrobial Resistance: a critical perspective. J Glob Antimicrob Resist. 2021 Oct 22:S2213-7165(21)00222-8. doi: 10.1016/j.jgar.2021.10.007.
  20. Barnabas R, Abhilash K, Varghese GM, Shubanker M, Ramya I, Prakash J. Prospective study to assess the treatment modalities and fever defervescence in patients with scrub typhus from a tertiary care centre in South India. J Vector Borne Dis. 2021 Jan-Mar;58(1):33-38. doi: 10.4103/0972-9062.321748.
  21. George B, Kulkarni U, Lionel S, Devasia AJ, Aboobacker FN, Lakshmi KM, Selvarajan S, Korula A, Rose W, Varghese GM, Rupali P, V B, Michael JS, Abraham A, Abraham A, Mathews V. Haploidentical transplantation is feasible and associated with reasonable outcomes despite major infective complications - a single center experience from India. Transplant Cell Ther. 2021 Oct 1:S2666-6367(21)01262-8. doi: 10.1016/j.jtct.2021.09.020.
  22. Devasagayam E, Dayanand D, Kundu D, Kamath MS, Kirubakaran R, Varghese GM. The burden of scrub typhus in India: A systematic review. PLoS Negl Trop Dis. 2021 Jul 27;15(7):e0009619. doi: 10.1371/journal.pntd.0009619.
  23. Gunasekaran K, Bal D, Varghese GM. Scrub Typhus and Other Rickettsial Infections. Indian J Crit Care Med. 2021 May;25(Suppl 2):S138-S143. doi: 10.5005/jp-journals-10071-23841.
  24. Mannam P, Arvind VH, Koshy M, Varghese GM, Alexander M, Elizabeth SM. Neuromelioidosis: A Single-Center Experience with Emphasis on Imaging. Indian J Radiol Imaging. 2021 Jan;31(1):57-64. doi: 10.1055/s-0041-1729125.
  25. Manesh A, Varghese GM; CENDRIC Investigators and Collaborators. Rising antimicrobial resistance: an evolving epidemic in a pandemic. Lancet Microbe. 2021 Jul 1. doi: 10.1016/S2666-5247(21)00173-7.
  26. Gupta A, Goyal-Honavar A, Jonathan GE, Prabhu K, Varghese GM, Rupali P, Chacko AG. Adapting management strategies for sellar-suprasellar lesions during the COVID-19 pandemic: a pragmatic approach from the frontline. Br J Neurosurg. 2021 Jun 21:1-8. doi: 10.1080/02688697.2021.1940852.
  27. Thomas VV, Kumar SE, Alexander V, Nadaraj A, Vijayalekshmi B, Prabhu S, Kumar S, Murugabharathy K, Thomas SM, Hansdak S, Carey R, Iyyadurai R, Pichamuthu K, Abhilash KPP, Varghese GM, Nair S, Goel A, Jeyaseelan L, Zachariah U, Zachariah A, Eapen CE. Plasma Von Willebrand Factor Levels Predict Survival in COVID-19 Patients Across the Entire Spectrum of Disease Severity. Indian J Hematol Blood Transfus. 2021 Jun 20:1-8. doi: 10.1007/s12288-021-01459-0.
  28. Salje J, Weitzel T, Newton PN, Varghese GM, Day N. Rickettsial infections: A blind spot in our view of neglected tropical diseases. PLoS Negl Trop Dis. 2021 May 13;15(5):e0009353. doi: 10.1371/journal.pntd.0009353.
  29. Ueland T, Astrup E, Otterdal K, Lekva T, Janardhanan J, Prakash JAJ, Thomas K, Michelsen AE, Aukrust P, Varghese GM, Damås JK. Secreted Wnt antagonists in scrub typhus. PLoS Negl Trop Dis. 2021 Apr 29;15(4):e0009185. doi: 10.1371/journal.pntd.0009185.
  30. Varghese L, Kurien R, Diana Sahni R, Manesh A, Mary Cherian L, Peter D, Dayanand D, Sarojini Michael J, Thomas M, Rupa V, Pulimood S, Varghese GM. Rhinofacial conidiobolomycosis: Clinical and microbiological characterisation and shift in the management of a rare disease. Mycoses. 2021 Apr 29. doi: 10.1111/myc.13294.
  31. Demosthenes JP, Fletcher G, Zachariah UG, Varghese GM, Pulimood SA, Abraham P, Kannangai R. Chronic Immune Activation among Treatment Naïve HIV/ HBV Coinfected Individuals from Southern India. Curr HIV Res. 2021 May 6. doi: 10.2174/1570162X19666210506160642.
  32. Mammen MD, Sahni RD, Varghese GM, Rupa V. Clinical utility of antifungal susceptibility testing in patients with fungal rhinosinusitis. Indian J Med Microbiol. 2021 Apr 24:S0255-0857(21)00060-8. doi: 10.1016/j.ijmmb.2021.04.005.
  33. WHO Solidarity Trial Consortium, Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q etal. Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184.
  34. Steve RJ, Alex D, Yesudhason BL, Prakash JAJ, Mathews NS, Daniel D, Ramalingam VV, Demosthenes JP, Ghale BC, Anantharam R, Rebekah G, Rupali P, Varghese GM, Kannangai R. Autoantibodies among HIV-1 infected individuals and the effect of Anti-retroviral therapy (ART) on it. Curr HIV Res. 2021 Feb 17. doi: 10.2174/1570162X19666210217120337.
  35. Varghese GM. The Search for Effective Empiric Therapy for Acute Undifferentiated Febrile Illness. Clin Infect Dis. 2020 Sep 29:ciaa1490. doi: 10.1093/cid/ciaa1490.
  36. Kannan K, John R, Kundu D, Dayanand D, Abhilash KPP, Mathuram AJ, Zachariah A, Sathyendra S, Hansdak SG, Abraham OC, Gunasekaran K, Iyadurai R, Abraham AM, Prakash JAJ, Yesudhason BL, Veeraraghavan B, Kavitha ML, Jose LR, Sumana MN, Saravu K, Varghese GM. Performance of molecular and serologic tests for the diagnosis of scrub typhus. PLoS Negl Trop Dis. 2020 Nov 12;14(11):e0008747. doi: 10.1371/journal.pntd.0008747. 
  37. Devi YD, Devi A, Gogoi H, Dehingia B, Doley R, Buragohain AK, Singh S, Borah PP,  Rao CD, Ray P, Varghese GM, Kumar S, Namsa ND. Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics. Heliyon. 2020; 6: e05760.
  38. Varghese L, Cherian LM, Varghese GM. Actinomycosis: An Unusual Cause of Maxillary Sinusitis. Ear Nose Throat J. 2020 Oct 13:145561320965207. doi: 10.1177/0145561320965207.
  39. John R, Varghese GM. Scrub typhus: a reemerging infection. Curr Opin Infect Dis. 2020; 33:365-371.
  40. Varghese L, Laxmanan S, Varghese GM. Mucosal Leishmaniasis Due to Leishmania donovani-A Rare Presentation. Ear Nose Throat J. 2020 doi: 10.1177/0145561320952186.
  41. Varghese GM, John R, Manesh A, Karthik R, Abraham OC. Clinical management of COVID-19. Indian J Med Res. 2020;151(5):401-410.
  42. Varghese GM, John R. COVID-19 in India: Moving from containment to mitigation. Indian J Med Res. 2020; 151:136-39.
  43. Bhatt AN, Tharyan P, Michael JS, Christopher DJ, Varghese GM, Sathyendra S, Rajan SJ, George K, Prasad JH. Treatment Outcomes with Daily Self-Administered Treatment and Thrice-Weekly Directly-Observed Treatment in Two Cohorts of Newly-Diagnosed, Sputum-Positive Adults with Pulmonary Tuberculosis. Indian J Tuberc. 2020; 67:105-111.
  44. Demosthenes JP, Sachithanandham J, Fletcher GJ, Zachariah UG, Varghese GM, John Daniel HD, Jeyaseelan L, Abraham P, Kannangai R. Characteristics of treatment-naïve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South India. Indian J Med Microbiol. 2019;37:219-224.
  45. GUaRDIAN Consortium, Sivasubbu S, Scaria V. Genomics of rare genetic diseases-experiences from India. Hum Genomics. 2019; 14:52. doi: 10.1186/s40246-019-0215-5.
  46. Varghese GM, Turaka VP, Janardhanan J, Yadav S, Lakshmi KM, Vijayakumar TS, Cherayil B. Serum siderocalin in patients with tuberculosis and HIV infection. Int J Infect Dis. 2019. pii: S1201-9712(19)30227-9. doi: 10.1016/j.ijid.2019.05.020.
  47. Ralph R, Prabhakar AT, Sathyendra S, Carey R, Jude J, Varghese GM. Scrub Typhus-Associated Opsoclonus: Clinical Course and Longitudinal Outcomes in an Indian Cohort. Ann Indian Acad Neurol. 2019;22:153-158.
  48. Manesh A, Barnabas R, Mani S, Karthik R, Abraham OC, Chacko G, Kannangai R, Varghese GM. Symptomatic HIV CNS viral escape among patients on effective cART. Int J Infect Dis. 2019. pii: S1201-9712(19)30162-6. doi: 10.1016/j.ijid.2019.03.033.
  49. Koshy M, Jagannati M, Ralph R, Victor P, David T, Sathyendra S, Veeraraghavan B, Varghese GM. Clinical Manifestations, Antimicrobial Drug Susceptibility Patterns, and Outcomes in Melioidosis Cases, India. Emerg Infect Dis. 2019; 25: DOI: 10.3201/eid2502.170745.
  50. Ramalingam VV, Subramanian S, Fletcher GJ, Rupali P, Varghese G, Pulimood S, Jeyaseelan L, Nandagopal B, Sridharan G, Kannangai R. Interaction of human immunodeficiency virus-1 and human immunodeficiency virus-2 capsid amino acid variants with human tripartite motif 5α protein SPRY domain and its association with pathogenesis. Indian J Med Microbiol. 2019;37:574-583. doi: 10.4103/ijmm.IJMM_20_109.
  51. Mukhopadhyay C, Shaw T, Varghese GM, Dance DAB. Melioidosis in South Asia (India, Nepal, Pakistan, Bhutan and Afghanistan). Trop Med Infect Dise  2018; 3: 51 doi: 10.3390/tropicalmed302005.
  52. Ramalingam VV, Demosthenes JP, Ghale BC, Rupali P, Varghese GM, Abraham OC, et al. Frequency of cross-resistance to rilpivirine and etravirine among HIV-1 subtype C infected individuals failing nevirapine/efavirenz based ART regimen. Infect Dis (Lond). 2018;29:1-4.
  53. Mani SSR, Gunasekaran K, Iyyadurai R, Prakash JAJ, Veeraraghavan B, Mishra AK, Sabnis K, Victor PJ, Martin S, Chandiraseharan VK, Hansdak SG, Varghese GM. Clinical spectrum, susceptibility profile, treatment and outcome of culture-confirmed brucellosis from South India. Indian J Med Microbiol. 2018;36:289-292.
  54. Varghese GM, Rajagopal VM, Trowbridge P, Purushothaman D, Martin SJ. Kinetics of IgM and IgG antibodies after scrub typhus infection and the clinical implications. Int J Infect Dis. 2018; 71:53-55.
  55. Jagannath S, Sachithanandham J, Ramalingam VV, Demosthenes JP, Abraham AM, Zachariah A, Varghese GM, Kannangai R. BK virus characterisation among HIV-1-Infected individuals and its association with immunosuppression.  Indian J Med Microbiol. 2018;36:172-177.
  56. Karthik G, Sudarsan TI, Peter JV, Sudarsanam T, Varghese GM, Kundavaram P, Sathyendra S, Iyyadurai R, Pichamuthu K. Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection. World J Crit Care Med. 2018;7:16-23. doi: 10.5492/wjccm.
  57. Manesh A, Mani RS, Pichamuthu K, Jagannati M, Mathew V, Karthik R, Abraham OC, Chacko G, Varghese GM. Failure of Therapeutic Coma in Rabies Encephalitis. Am J Trop Med Hyg. 2018; 98: 207-2010.
  58. Korula A, Abraham A, Abubacker FN, Viswabandya A, Lakshmi KM, Abraham OC, Rupali P, Varghese GM, Michael JS, Srivastava A, Mathews V, George B. Invasive fungal infection following chemotherapy for acute myeloid leukaemia-Experience from a developing country. Mycoses. 2017 60:686-691. doi: 10.1111/myc.12646.
  59. Trowbridge P, P D, Premkumar PS, Varghese GM. Prevalence and risk factors for scrub typhus in South India. Trop Med Int Health. 2017 Feb 7. doi: 10.1111/tmi.12853.
  60. Wattal C, Chakrabarti A, Oberoi JK, Donnelly JP, Barnes RA, Sherwal BL, Goel N, Saxena S, Varghese GM, Soman R, Loomba P, Tarai B, Singhal S, Mehta N, Ramasubramanian V, Choudhary D, Mehta Y, Ghosh S, Muralidhar S, Kaur R. Issues in antifungal stewardship: an opportunity that should not be lost. J Antimicrob Chemother. J Antimicrob Chemother. 2017; 72:969-974.
  61. Shaikh IAA, Abhilash KPP, Mitra S, Jayakaran JAJ, Trinity P, Varghese GM. Does the presence of an eschar correlate with severity of scrub typhus infection? Ind J Med Sci. 2017;69:36-39.
  62. Abhilash KP, Jeevan JA, Mitra S, Paul N, Murugan TP, Rangaraj A, David S, Hansdak SG, Prakash JA, Abraham AM, Ramasami P, Sathyendra S, Sudarsanam TD, Varghese GM. Acute Undifferentiated Febrile Illness in Patients Presenting to a Tertiary Care Hospital in South India: Clinical Spectrum and Outcome. J Glob Infect Dis. 2016;8:147-154.
  63. Varghese GM, Raj D, Francis MR, Sarkar R, Trowbridge P, Muliyil J. Epidemiology and Risk Factors of Scrub Typhus in South India. Indian J Med Res. 2016; 141:76-81.
  64. Manesh A, John AO, Mathew B, Varghese L, Rupa V, Zachariah A, Varghese GM. Posaconazole: an emerging therapeutic option for invasive rhino-orbito-cerebral mucormycosis. Mycoses 2016 Jul 22. doi: 10.1111/myc.12529.
  65. Takeuchi M, Dahabreh IJ, Nihashi T, Iwata M, Varghese GM, Terasawa T. Nuclear Imaging for Classic Fever of Unknown Origin: Meta-Analysis. J Nucl Med. 2016; 57:1913-1919.
  66. Janardhanan J, Patole S, Varghese L, Rupa V, Tirkey AJ, Varghese GM. Elusive treatment for human rhinosporidiosis. Int J Infect Dis. 2016; 48: 3-4. doi: 10.1016/j.ijid.2016.04.013.
  67. Suraj S, Stephen E, Sen I, Radger A, Nayak S, Varghese GM, Antonisamy B, Agarwal S. Prevalence and risk factors of peripheral arterial occlusive disease in HIV infected patients. Indian J Applied Res 2016; 6: 30-33.
  68. Rahi M, Gupte MD, Bhargava A, Varghese GM, Arora R. DHR-ICMR Guidelines for diagnosis and management of Rickettsial diseases in India. Indian J Med Res. 2015;141: 417-22.
  69. Varghese GM, Janardhanan J, Mahajan SK, Tariang D, Trowbridge P, Prakash JAJ, David T, Sathendra S, Abraham OC. Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi from Patients with Scrub Typhus in India. Emerg Infect Dis. 2015; 21: 64 – 69. 
  70. Das MK, Bishwal SC, Das A, Dabral D, Badireddy VK, Pandit B, Varghese GM, Nanda RK. Deregulated tyrosine-phenylalanine metabolism in pulmonary tuberculosis patients. J. Proteome Res 2015. 14: 1947 – 56. DOI: 10.1021/acs.jproteome.5b00016.
  71. Deodhar D, Varghese GM, Balaji V, John J, Rebekah G, Janardhanan J, Jeyaraman R, Jasmine S, Mathews P. Prevalence of Toxin Genes among the Clinical Isolates of Staphylococcus aureus and its Clinical Impact. J Glob Infect Dis. 2015.
  72. Abhilash KP, Gunasekaran K, Mitra S, Patole S, Sathyendra S, Jasmine S, Varghese GM. Scrub typhus meningitis: An under-recognized cause of aseptic meningitis in India. Neurol India. 2015; 63: 209-14.
  73. Peter JV, Sudarsan TI, Prakash JAJ, Varghese GM. Severe scrub typhus infection: Clinical features, diagnostic challenges and management. World J Crit Care Med. 2015; 4: 244 – 250. 
  74. Varghese L, Chacko R, Varghese GM, Job A. Septic arthritis of the temporomandibular joint caused by Aspergillus flavus infection as a complication of otitis externa. Ear Nose Throat J. 2015; 94: E 24 – 26.
  75. Cherian LM, Varghese L, Panchatcharam BS, Parmar HV, Varghese GM. Nasal conidiobolomycosis: A successful treatment option for localized disease. J Postgrad Med. 2015; 61:143-144.
  76. Thuppal SV, Kang G, Abraham OC, Noubary F, Cohen JT, Mwamburi M, Muliyil J, Wanke CA, Varghese GM, Rupali P, Karthik R, Sathasivam R, Clarance P, Pulimood SA, Peter D, George L. Clinical outcomes, treatment costs, and quality of life in patients with HIV on zidovudine and tenofovir containing regimen in India: A pragmatic randomized clinical trial Running head: zidovudine vs. tenofovir regimen in India. Trans R Soc Trop Med Hyg. 2015. 109: 379 – 85. 
  77. Janardhanan J, Trowbridge P, Varghese GM. Diagnosis of scrub typhus. Expert Rev Anti Infect Ther. 2014; 12: 1533-40. 
  78. Rakesh PS, Alex RG, Varghese GM, Mathew P, David T, Manipadam MT, Nair S, Abraham OC. Kikuchi-Fujimoto Disease: Clinical and Laboratory Characteristics and Outcome. J Glob Infect Dis. 2014;6:147-50.
  79. Griffith M, Peter JV, Karthik G, Ramakrishna K, Prakash JAJ, Kalki RC, Varghese GM, Chrispal A, Pichamuthu K, Iyyadurai R, Abraham OC. Profile of organ dysfunction and predictors of mortality in severe scrub typhus infection requiring intensive care admission. Indian J Crit Care Med. 2014; 18: 497 – 502.
  80. Otterdal K, Janardhanan J, Astrup E, Ueland T, Prakash JA, Lekva T, Abraham OC, Thomas K, Damås JK, Mathews P, Mathai D, Aukrust P, Varghese GM. Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus. J Infect. 2014. pii: S0163-4453(14)00196-0. doi: 10.1016/j.jinf.2014.06.018.
  81. Astrup E, Janardhanan J, Otterdal K, Ueland T, Prakash JA, Lekva T, Strand OA, Abraham OC, Thomas K, Damås JK, Mathews P, Mathai D, Aukrust P, Varghese GM. Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality. PLoS Negl Trop Dis. 2014; 8(2):e2648. doi: 10.1371/journal.pntd.0002648.
  82. Patole S, Burza S, Varghese GM. Multiple relapses of visceral leishmaniasis in a patient with HIV in India: A treatment challenge. Int J Infect Dis. 2014; 25:204-6. doi: 10.1016/j.ijid.2014.02.015. 
  83. Janardhanan J, Prakash JA, Abraham OC, Varghese GM. Comparison of Conventional and Nested PCR for Diagnostic Confirmation and Genotyping of Orientia tsutsugamushi. Diagn Microbiol Infect Dis. 2014; 79(1):7-9. doi: 10.1016.  
  84. Varghese GM, Trowbridge P, Janardhanan J, Thomas K, Peter JV, Mathews P, Abraham OC, Kavitha ML.Clinical Profile and Improving Mortality Trend of Scrub Typhus in South India.Int J Infect Dis.2014;23:39-43.    
  85. Singhi S, Chaudhary D, Varghese GM, Bhalla A, Kalantri S, Peter JV. Mishra R, Bhagchandani R, Chugh TD, Rungta N. Tropical Fever – Management Guidelines. Indian J Crit Care Med. 2014; 18: 62 – 69.  
  86. Kundavaram A, Francis NR, Jude APJ, Varghese GM. Acute infectious purpura fulminans due to spotted fever. J Postgrad Med. 2014; 60:198-9.
  87. Peter JV, Griffith M, Prakash JA, Christpal A, Pichamuthu K, Varghese GM. Anti-nuclear antibody (ANA) expression in severe scrub typhus infection - preliminary observations. J Glob Infect Dis. 2014; 6: 195-96.  
  88. Abhilash KPP,  Sohini D, Varghese GM. Scrub typhus presenting as acute abdomen. J Glob Infect Dis. 2014; 6: 17 – 18.
  89. Janardhanan J, Martin SJ, Astrup E, Manikandan V, Aukrust P, Abraham OC, Varghese GM. Single Nucleotide Polymorphisms In toll-like receptor (TLR)2, TLR4 and heat shock protein 70 Genes And Susceptibility To Scrub Typhus. J Hum Genet. 201; 58:707-10.
  90. Varghese GM, Janardhanan J, Trowbridge P, Peter JV, Prakash JAJ, Sathyendra S, Thomas K, David TS, Kavitha ML, Abraham OC, Mathai D. Scrub Typhus in South India: Clinical and Laboratory Manifestations, Genetic Variability and Outcome. Int J Infect Dis. 2013;17:e981-7.
  91. Kundavaram AP, Jonathan A, Nathaniel S, Varghese GM. Eschar in Scrub typhus: A valuable clue to diagnosis. J Postgrad Med. 2013; 59:177-78.
  92. Varghese GM, Janardhanan J, Ralph R, Abraham OC. The Twin Epidemics of Tuberculosis and HIV. Curr Infect Dis Rep 2013; 15:77-84.
  93. Abhilash KP, Roshine MK, Vandana K, Varghese GM. A probable case of acquired toxoplasmosis presenting as pyrexia of unknown origin in an immunocompetent individual. Int J Infect Dis. 2013; 17: e1067 – 68.  
  94. Emerson P, Philip A, Varghese GM, Thomas R. Tuberculous osteomyelitis of the hyoid bone: a case report. Case Rep Otolaryngol. 2013; 2013:549564.
  95. Varghese GM, Mathew A, Kumar S, Trowbridge P, Abraham OC, Mathai E, Mathai D. Differential diagnosis of Scrub Typhus Meningitis from Pyogenic Meningitis Using Clinical and Laboratory Features. Neurol India 2013; 61: 17-20.
  96. Thumaty DB, Varghese GM. Cutaneous Anthrax: An unusual cause of preseptal cellulites. Med ej. 2013; 1: 20101253.
  97. Mathuram A, van Rijn R, Varghese GM. Salmonella typhi rib osteomyelitis with abscess mimicking a ‘cold abscess’. J Glob Infect Dis. 2013; 5: 80-81.
  98. Ramakrishna K, Sampath S, Chacko J, Chacko B, Narahari DL, Veerendra HH, Moorthy M, Krishna B, Chekuri VS, Raju RK, Shanmugasundaram D, Pichamuthu K, Abraham AM, Abraham OC, Thomas K, Mathews P, Varghese GM, Rupali P, Peter JV. Clinical Profile and Predictors of Mortality of Severe Pandemic (H1N1) 2009 Virus Infection Needing Intensive Care: A Multi-Centre Prospective Study from South India. J Glob Infect Dis. 2012;4:145-52.
  99. Ramachandran J, Ajjampur SSR, Chandramohan A, Varghese GM. Cases of Human Fascioliasis in India: Tip of the Iceberg. J Postgrad Med. 2012; 58: 150 – 52.
  100. Varghese GM, Eapen EP, Pulimood S. Ecthyma gangrenosum of a single limb. Indian J Crit Care Med 2011; 15: 177 – 78.
  101. Balaji GG, Mathuram AJ, Arokiaraj J, Varghese GM. A Rare Case of Cryptococcal Infection of Talus with Pathological Fracture that Healed with Medical Management. J Foot Ankle Surg. 2011; 50:740-3.
  102. Varghese GM, Trowbridge P, Doherty T. Investigating and Managing Pyrexia of Unknown Origin in Adults. BMJ 2010; 341:878 - 81.
  103. Varghese GM. Scrub typhus: An emerging threat. Curr Med Issues 2010; 12:16 - 19.
  104. Varghese GM, Sobel JD. Fungal Endocarditis. Curr Infect Dis Rep 2008; 10: 275 - 79.
  105. Thomas G, Varghese GM. Heat stroke and heat related illnesses. Phys Dige 2008;17: 66 – 71.
  106. Varghese GM, Abraham OC, Mathai D, Thomas K, Aaron R, Kavitha ML, Mathai E. Scrub typhus among hospitalised patients with febrile illness in South India: magnitude and clinical predictors. J Infect 2006; 52: 56 – 60.
  107. Somashekar HR, Moses PD , Pavithran S, Mathew LG, Agarwal I, Rolain JM, Raoult D, Varghese GM, Mathai E. Magnitude and Features of Scrub Typhus and Spotted Fever in Children in India. J Trop Pediatr 2006; 52: 228-29.
  108. Thambu D, Pichamuthu K, Varghese GM, Subramaniam S. Community-acquired, fatal extended spectrum beta lactamase producing Klebsiella pneumoniae splenic abscess and sepsis. J Postgrad Med. 2006; 52: 328 – 29.
  109. Varghese GM, John G, Thomas K, Abraham OC, Mathai D. Predictors of multiorgan dysfunction in heatstroke. Emerg Med J 2005; 22:185–187.
  110. Varghese GM, Shenoy M, Subramaniam S, Peter S, Mathai D. Colonic malignancy with recurrent bacteremia presenting as pyrexia of unknown origin. J Intern Med 2004; 255: 692 –  693.
  111. Varghese GM, Pise G, Michael JS, Jacob M, George R. Disseminated Penicillium marneffei infection in a Human Immunodeficiency Virus infected individual. J Postgrad Med. 2004; 50:235-6.
  112. Isaac R, Varghese GM, Joseph I, Manjula J, Mathai E. Scrub typhus: Prevalence and Diagnostic Issues in Rural Southern India. Clin Infect Dis. 2004; 39: 1395 – 96.
  113. Varghese GM, Abraham OC, Mathai D. Post-exposure prophylaxis for blood borne viral infections in health care workers. Postgrad Med J 2003; 79:324-328.
  114. Mathai E, Rolain JM, Verghese GM, Abraham OC, Mathai D, Mathai M, Lecam C, Raoult D. Outbreak of scrub typhus in southern India during cooler months. Ann N Y Acad Sci  2003; 990: 359 – 364.
  115. Mathai E, Rolain JM, Varghese L, Mathai M, Jasper P, Verghese GM, Raoult D. Scrub typhus during pregnancy in India. Trans R Soc Trop Med Hyg. 2003;97:570-2.
  116. Chandy SJ, Chandy ST, Swaminathan S, Varghese GM, Abraham OC, Mathai D. Pacemaker endocarditis caused by Pseudomonas aeruginosa treated successfully. J Assoc Physicians India 2003; 51: 1021- 22.

Grants,Awards and Certifications

Grants :

                                 

                                  ONGOING RESEARCH PROJECTS

S. No.

Title of Project

 Source of Funds

1

Risks of bacterial and fungal superinfection in patients with COVID-19 stratified by new and pre-existing immunosuppression: a retrospective, observational, multisite, multinational cohort study.

University of Queensland

1

‘Improving treatment outcomes in severe scrub typhus: a multicentre randomized controlled trial with pharmacokinetic/pharmacodynamic assessment and molecular characterization of Orientia tsutsugamushi’

India Alliance DBT,

Wellcome trust

2

Characterization of Multi-Drug Resistant Gram Negative Bacteremic Isolates from Critically Ill Patients

University of Dundee

3

Computational and Experimental Platform for High Resolution Terapixel Imaging of ex-vivo Human Brains using rabid brain as the model

Government of India to IIT Madras

4

Prognostication of Oxygen Requirement In non-severe SARS-CoV-2 infection

MSF India

 

    

Awards & Prizes :

National Award for Excellence in Clinical Research – 2020

Senior Fellowship awarded by Wellcome Trust DBT Alliance – 2017

Fellow of Royal College of Physicians (FRCP) – 2015

Fellow of the Infectious Diseases Society of America (FIDSA) – 2014

Dr. MG Alexander Award for Tropical Medicine - 2014

Linnaeus-Palme Visiting Professor to Karolinska Institute, Stockholm, Sweden – 2013

Guerrant International Young Investigator Award (Infectious Disease Society of America)- 2011

Fellow of the Royal Society of Tropical Medicine & Hygiene (UK) – 2006

Best Paper Award in Critical Care at Asia Pacific Congress on Diseases of the Chest - 2001

Niamathullah Memorial prize in Nephrology – 2001

Gwenda Lewis Prize in Anaesthesiology – 1991

Captain Jaisingh Jadev Merit Certificate in Paediatrics – 1991 

Languages

Language Proficiency :

Translation Services :

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