Evan Macosko is an institute member at the Broad Institute of MIT and Harvard, where he directs a lab located in the Stanley Center for Psychiatric Research. He is also an assistant professor and attending psychiatrist at Massachusetts General Hospital. He and his lab invent and apply genomics technology to the study of brain diseases. Recently, his lab developed Slide-seq, a tool for localizing the expression of all genes in situ. They are applying this technology — together with high-throughput single-cell analysis — to uncover pathogenic mechanisms of neuropsychiatric diseases.

Macosko received an A.B. in chemistry from Harvard College, and his M.D. from Weill Cornell Medical College. He earned a Ph.D. from The Rockefeller University in the lab of Cori Bargmann, where he characterized neural circuitry responsible for C. elegans social behavior. He completed residency training in psychiatry at McLean and Massachusetts General Hospitals. As a postdoctoral fellow with Steven McCarroll, he developed Drop-seq, a technology for measuring gene expression in thousands of individual cells at once.