Auriol Purdie
Dr, University of Sydney
Location: Australia
Consulting Services
Areas Of Interest
Professional Narrative
Employment
Education
Referees
Karren Plain, University of Sydney.
“Dr”
Publications
1. Pooley, H.B., et al., IP10 is a predictor of successful vaccine protection against paratuberculosis infection in sheep. Vaccine, 2023. 41(1): p. 274-283.
2. Wright, K., et al., Mycobacterium avium subsp. paratuberculosis exploits miRNA expression to modulate lipid metabolism and macrophage polarisation pathways during infection. Scientific Reports, 2022. 12(1): p. 9681.
3. Purdie, A.C., et al., Correlates of vaccine protection against Mycobacterium avium sub-species paratuberculosis infection revealed in a transcriptomic study of responses in Gudair® vaccinated sheep. Frontiers in Veterinary Science, 2022. 9.
4. Pooley, H.B., et al., Sheep vaccinated against paratuberculosis have increased levels of B cells infiltrating the intestinal tissue. Veterinary Immunology and Immunopathology, 2022. 252: p. 110482.
5. Orr, B., et al., Leptospirosis is an emerging infectious disease of pig-hunting dogs and humans in North Queensland. PLoS Neglected Tropical Diseases, 2022. 16(1): p. e0010100.
6. Wright, K., et al., Infection-induced miR-126 suppresses tsc1-and cxcl12a-dependent permissive macrophages during mycobacterial infection. bioRxiv, 2021: p. 2021.10. 07.463594.
7. Wright, K., et al., Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis. PLoS Pathogens, 2021. 17(4): p. e1009186.
8. Whittington, R., et al., Vaccine compositions. 2021, US Patent App. 16/760,842.
9. Smith, A., et al., Animal welfare along the smallholder pig value chain in Vietnam: Current status, legal perspectives and way forward. ILRI Research Brief, 2021.
10. Wright, K., et al., Comparison of methods for miRNA isolation and quantification from ovine plasma. Scientific reports, 2020. 10(1): p. 825.
11. Purdie, A.C., K. Plain, and K. de Silva, Immune fitness as a measure of animal health, welfare and productivity in the feedlot. The Journal of Immunology, 2020. 204(1_Supplement): p. 92.3-92.3.
12. Plain, K.M., I. Marsh, and A.C. Purdie, Diagnosis of paratuberculosis by PCR, in Paratuberculosis: organism, disease, control. 2020, CABI Wallingford UK. p. 305-332.
13. Wright, K., et al., Biomarkers for detecting resilience against mycobacterial disease in animals. Infection and Immunity, 2019. 88(1): p. e00401-19.
14. Purdie, A.C., et al., Gene expression profiles during subclinical Mycobacterium avium subspecies paratuberculosis infection in sheep can predict disease outcome. Scientific reports, 2019. 9(1): p. 1-15.
15. Pooley, H.B., et al., The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep. BMC veterinary research, 2019. 15(1): p. 1-12.
16. Pooley, H., et al., Novel methods for assessing the efficacy of vaccines against Johne’s Disease. 2019.
17. Johansen, M.D., et al., Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages. Microbial pathogenesis, 2019. 130: p. 44-53.
18. Begg, D., et al., The immunogenicity and tissue reactivity of Mycobacterium avium subsp paratuberculosis inactivated whole cell vaccine is dependent on the adjuvant used. Heliyon, 2019. 5(6): p. e01911.
19. Pooley, H.B., et al., Integrated vaccine screening system: using cellular functional capacity in vitro to assess genuine vaccine protectiveness in ruminants. Pathogens and disease, 2018. 76(3): p. fty029.
20. Johansen, M.D., et al., Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. Developmental & Comparative Immunology, 2018. 88: p. 169-172.
21. Johansen, M.D., et al., Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection. bioRxiv, 2018: p. 319202.
22. Johansen, M.D., et al., Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & shellfish immunology, 2018. 83: p. 238-242.
23. Johansen, M.D., et al., Pathogenic mycobacteria manipulate host low density lipoprotein metabolism. bioRxiv, 2018: p. 250548.
24. Johansen, M., et al., Sheep and cattle exposed to Mycobacterium avium subspecies paratuberculosis exhibit altered total serum cholesterol profiles during the early stages of infection. Veterinary immunology and immunopathology, 2018. 202: p. 164-171.
25. de Silva, K., et al., Defining resilience to mycobacterial disease: characteristics of survivors of ovine paratuberculosis. Veterinary immunology and immunopathology, 2018. 195: p. 56-64.
26. Britton, W., et al., Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. 2018.
27. Begg, D.J., et al., Immunopathological changes and apparent recovery from infection revealed in cattle in an experimental model of Johne’s disease using a lyophilised culture of Mycobacterium avium subspecies paratuberculosis. Veterinary microbiology, 2018. 219: p. 53-62.
28. Whittington, R., et al., Case definition terminology for paratuberculosis (Johne’s disease). BMC veterinary research, 2017. 13(1): p. 1-13.
29. Thirunavukkarasu, S., et al., IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria. PLoS One, 2017. 12(5): p. e0176400.
30. de Silva, K., et al., IFN-(gamma) fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria. 2017.
31. Begg, D., et al., Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation. Veterinary research, 2017. 48: p. 1-11.
32. Acharya, K.R., et al., Culture-independent identification of Mycobacterium avium subspecies paratuberculosis in ovine tissues: comparison with bacterial culture and histopathological lesions. Frontiers in Veterinary Science, 2017. 4: p. 232.
33. Swift, B., et al., Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle. BMC veterinary research, 2016. 12(1): p. 1-8.
34. Purdie, A., Gene expression analysis identifies genes differentially regulated in Bovine and Ovine models of Mycobacterium avium subspecies paratuberculosis exp. 2016.
35. Pooley, H.B., et al., A rapid method for quantifying viable Mycobacterium avium subsp. paratuberculosis in cellular infection assays. Applied and Environmental Microbiology, 2016. 82(18): p. 5553-5562.
36. Johansen, M., et al. The importance of cholesterol in MAP infection of ruminants. in 13. International Colloquium on Paratuberculosis (ICP 2016). 2016.
37. de Silva, K., K. Plain, and A. Purdie, Diagnostic, predictive and preventative tools for Johne’s disease in sheep and cattle. 2016.
38. de Silva, K., Immunological nature of sheep inherently resistant to MAP infection. 2016.
39. Begg, D., et al., Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle. 2016.
40. Plain, K.M., et al., Efficient, validated method for detection of mycobacterial growth in liquid culture media by use of bead beating, magnetic-particle-based nucleic acid isolation, and quantitative PCR. Journal of Clinical Microbiology, 2015. 53(4): p. 1121-1128.
41. Gurung, R., et al., Development of 316v antibody enzyme-linked immunosorbent assay for detection of paratuberculosis in sheep. OIE Revue Scientifique et Technique, 2015. 34(3): p. 869-879.
42. de Silva, K., et al., CD4+ T-cells, γδ T-cells and B-cells are associated with lack of vaccine protection in Mycobacterium avium subspecies paratuberculosis infection. Vaccine, 2015. 33(1): p. 149-155.
43. Begg, D., et al., Specific faecal antibody responses in sheep infected with Mycobacterium avium subspecies paratuberculosis. Veterinary Immunology and Immunopathology, 2015. 166(3-4): p. 125-131.
44. Thirunavukkarasu, S., et al., Expression of genes associated with cholesterol and lipid metabolism identified as a novel pathway in the early pathogenesis of Mycobacterium avium subspecies paratuberculosis-infection in cattle. Veterinary immunology and immunopathology, 2014. 160(3-4): p. 147-157.
45. Plain, K.M., et al., High-throughput direct fecal PCR assay for detection of Mycobacterium avium subsp. paratuberculosis in sheep and cattle. Journal of clinical microbiology, 2014. 52(3): p. 745-757.
46. Gurung, R.B., et al., Cellular and humoral immune responses in sheep vaccinated with candidate antigens MAP2698c and MAP3567 from Mycobacterium avium subspecies paratuberculosis. Frontiers in Cellular and Infection Microbiology, 2014. 4: p. 93.
47. Gurung, R.B., et al., Antigenicity in sheep of synthetic peptides derived from stress-regulated Mycobacterium avium subsp. paratuberculosis proteins and comparison with recombinant protein and complex native antigens. Veterinary Immunology and Immunopathology, 2014. 158(1-2): p. 46-52.
48. Gurung, R.B., et al., Lymphoproliferative and Gamma Interferon Responses to Stress-Regulated Mycobacterium avium subsp. Gurungparatuberculosis Recombinant Proteins. 2014.
49. Gurung, R.B., et al., Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins. Clinical and Vaccine Immunology, 2014. 21(6): p. 831-837.
50. Gurung, R.B., et al., Immunoreactivity of protein tyrosine phosphatase A (PtpA) in sera from sheep infected with Mycobacterium avium subspecies paratuberculosis. Veterinary immunology and immunopathology, 2014. 160(1-2): p. 129-132.
51. de Silva, K., et al., Lymphoproliferative and Gamma Interferon. 2014.
52. Whittington, R.J., et al., Development and validation of a liquid medium (M7H9C) for routine culture of Mycobacterium avium subsp. paratuberculosis to replace modified Bactec 12B medium. Journal of Clinical Microbiology, 2013. 51(12): p. 3993-4000.
53. Plain, K.M., et al., Development and Validation of a Liquid. 2013.
54. Gurung, R.B., et al., Antigenicity of recombinant maltose binding protein-Mycobacterium avium subsp. paratuberculosis fusion proteins with and without factor Xa cleaving. Clinical and Vaccine Immunology, 2013. 20(12): p. 1817-1826.
55. de Silva, K., et al., Can early host responses to mycobacterial infection predict eventual disease outcomes? Preventive veterinary medicine, 2013. 112(3-4): p. 203-212.
56. Whittington, R.J., et al., Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection. Veterinary immunology and immunopathology, 2012. 148(1-2): p. 29-47.
57. Thirunavukkarasu, S., et al., Novel gene expression profile in blood cells from cattle experimentally exposed to Mycobacterium avium subsp. paratuberculosis (164.24). The Journal of Immunology, 2012. 188(1_Supplement): p. 164.24-164.24.
58. Purdie, A.C., et al., Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection. Comparative immunology, microbiology and infectious diseases, 2012. 35(2): p. 151-162.
59. Purdie, A., et al., Differential gene expression changes associated with sub-clinical Mycobacterium avium subsp. paratuberculosis infection in cattle: a transcriptomic study (160.2). The Journal of Immunology, 2012. 188(1_Supplement): p. 160.2-160.2.
60. Plain, K.M., et al., Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation. Veterinary immunology and immunopathology, 2012. 149(1-2): p. 28-37.
61. Gurung, R.B., et al., In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheep. Veterinary immunology and immunopathology, 2012. 149(3-4): p. 186-196.
62. Gurung, R.B., et al., In silico identification of epitopes in Mycobacterium avium subsp. paratuberculosis proteins that were upregulated under stress conditions. Clinical and Vaccine Immunology, 2012. 19(6): p. 855-864.
63. Gurung, R., et al., Immunogenicity evaluation of in silico identified Mycobacterium avium subsp paratuberculosis recombinant proteins that were upregulated under stress conditions (160.3). The Journal of Immunology, 2012. 188(1_Supplement): p. 160.3-160.3.
64. de Silva, K., et al., Early biomarkers of resistance and susceptibility to mycobacterial disease (160.1). The Journal of Immunology, 2012. 188(1_Supplement): p. 160.1-160.1.
65. Purdie, A.C., et al., Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review. Comparative Immunology, Microbiology and Infectious Diseases, 2011. 34(3): p. 197-208.
66. Plain, K.M., et al., Indoleamine 2, 3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections. Infection and immunity, 2011. 79(9): p. 3821-3832.
67. Purdie, A.C., et al., Comparative Immunology, Microbiology and Infectious Diseases. 2010.
68. Plain, K.M., et al., Toll-like receptor (TLR) 6 and TLR1 differentiation in gene expression studies of Johne's disease. Veterinary immunology and immunopathology, 2010. 137(1-2): p. 142-148.
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